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Case Reports
. 2021 Mar;56(3):696-700.
doi: 10.1038/s41409-020-01035-6. Epub 2020 Aug 25.

The great challenge of managing recipients of hematopoietic stem cell transplantation combined with COVID-19

Xuan Lu #  1 , Liang V Tang #  1 , Hua-Fang Wang  1 , Yong You  1 , Ya-Dan Wang  1 , Yu Hu  1 , Wei Shi  2   3 , Ling-Hui Xia  4
Affiliations
Case Reports

The great challenge of managing recipients of hematopoietic stem cell transplantation combined with COVID-19

Xuan Lu et al. Bone Marrow Transplant. 2021 Mar.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Clinical course of the HSCT recipients suffered from COVID-19.
a Patient 1. CT: bilateral patchy ground-glass opacities, more lesions in the lower lobe of the right lung, compared with the last imaging. X-ray: chest radiograph showed bilateral large blurred areas. b Patient 2. CT1: bilateral patchy ground-glass opacities. CT2: bilateral multiple ground-glass opacities, with partial consolidation. CT3: bilateral patchy ground-glass opacities, with partial resolution. PLT platelet, CRP C-reactive protein, FK506 tacrolimus, MMF mycophenolate mofetil, GVHD graft-versus-host disease, RNA+ positive test for SARS-CoV-2 RNA, RNA− negative test for SARS-CoV-2 RNA, IgM/IgG− negative test for antibodies to SARS-CoV-2.
Fig. 2
Fig. 2. Challenges of management for hematopoietic stem cell transplant recipients with COVID-19.
HSCT hematopoietic stem cell transplant, ATG antithymocyte globulin, FK506 tacrolimus, MMF mycophenolate mofetil, GGO ground-glass opacities, WBC white blood cell, IgM/IgG antibodies to SARS-CoV-2, GVHD graft-versus-host disease, ARDS acute respiratory distress syndrome, BM bone marrow.
Fig. 3
Fig. 3. Comparisons between the initial imaging findings of COVID-19 and those of before infection.
Patient 1: a 5 months before b infection onset; patient 2: c 2 months before d Infection onset.
See this image and copyright information in PMC

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