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Case Reports
. 2020 Aug;74(4):365-370.
doi: 10.18926/AMO/60376.

Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C

Masayuki Chuma  1 , Masateru Kondo  2 , Yoshito Zamami  2   3 , Kenshi Takechi  4 , Mitsuhiro Goda  2 , Naoto Okada  2 , Akitomo Shibata  5 , Mizuho Asada  6 , Jun Oto  7 , Hiroaki Yanagawa  4 , Keisuke Ishizawa  8   3
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Free article
Case Reports

Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C

Masayuki Chuma et al. Acta Med Okayama. 2020 Aug.
Free article

Abstract

Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.

Keywords: bacterial meningitis; cystatin C; sepsis; therapeutic drug monitoring; vancomycin,.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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