Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul 31:14:2633494120941480.
doi: 10.1177/2633494120941480. eCollection 2020 Jan-Dec.

Update on the management of poor ovarian response in IVF: the shift from Bologna criteria to the Poseidon concept

Panagiotis Drakopoulos  1 , Erlisa Bardhi  2 , Liese Boudry  2 , Alberto Vaiarelli  3 , Antonis Makrigiannakis  4 , Sandro C Esteves  5 , Herman Tournaye  2 , Christophe Blockeel  2
Affiliations
Review

Update on the management of poor ovarian response in IVF: the shift from Bologna criteria to the Poseidon concept

Panagiotis Drakopoulos et al. Ther Adv Reprod Health. .

Abstract

Despite the considerate progress to which assisted reproduction technology (ART) has been subject since 1978, some issues remain unresolved. Notably, the clinical management of patients with a poor ovarian response is still a challenge in everyday practice, frustrating to both the patient and the fertility expert. Poor ovarian responders (PORs) embody 9-24% of patients undergoing ovarian stimulation, meaning that up to one in four patients conceals a poor reproductive prognosis. The last decade has witnessed the attempts of the medical community to standardize diagnosis of POR with the developing of the Bologna Criteria and the subsequent evolution of the low prognosis patient elaborated in the POSEIDON classification. The aim of this article is to summarize all evidence concerning etiology and management of poor ovarian response, including the most recent advances and future prospects in this regard.

Keywords: Bologna criteria; IVF; Poseidon classification; poor ovarian responder (POR); poor ovarian response.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
SWOT analysis of the novel POSEIDON criteria.
See this image and copyright information in PMC

References

    1. Ubaldi FM, Rienzi L, Ferrero S, et al. Management of poor responders in IVF. Reprod Biomed Online 2005; 10: 235–246. - PubMed
    1. Vaiarelli A, Cimadomo D, Ubaldi N, et al. What is new in the management of poor ovarian response in IVF. Curr Opin Obstet Gynecol 2018; 30: 155–162. - PubMed
    1. Blumenfeld Z. What is the best regimen for ovarian stimulation of poor responders in ART/IVF. Front Endocrinol (Lausanne) 2020; 11: 192. - PMC - PubMed
    1. Blumenfeld Z. Premature ovarian failure: etiology and possible prevention. Expert Rev Endocrinol Metab 2009; 4: 173–181. - PubMed
    1. Goswami D, Conway GS. Premature ovarian failure. Hum Reprod Update 2005; 11: 391–410. - PubMed

LinkOut - more resources