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. 2020 Aug 21;99(34):e21926.
doi: 10.1097/MD.0000000000021926.

Intensive care unit acquired weakness: A protocol for an overview of systematic reviews and meta-analysis

Zheng Li  1 , Yitong Cai  2 , Qian Zhang  2 , Peng Zhang  3 , Ruixiang Sun  3 , Haijiao Jiang  3 , JingJing Wan  1 , Fang Wu  1 , Xiaoye Wang  3 , Xiubin Tao  1   3
Affiliations

Intensive care unit acquired weakness: A protocol for an overview of systematic reviews and meta-analysis

Zheng Li et al. Medicine (Baltimore). .

Abstract

Background: Intensive care unit-acquired weakness (ICU-AW) is an acquired neuromuscular lesion and a common occurrence in patients who are critically ill. There are already systematic reviews on ICU-AW. Therefore, we provide a protocol for an overview of systematic reviews to improve the effectiveness of the construction of an evidence-based practice for prevention of ICU-AW.

Methods: We will search the PubMed, CINAHL, EMBASE, and the Cochrane Library for the relevant systematic review or meta-analyses about ICU-AW. Study selection, data extraction, and the quality assessment of the included studies will be performed independently by 2 reviewers. And the methodological quality, report quality and evidence quality will be evaluated by Assessment of Multiple Systematic Reviews-2 tool, Preferred Reporting Items for Systematic Reviews and Meta Analyses Statement checklist and Grading of Recommendations Assessment, Development and Evaluation system, respectively.

Results: This overview of systematic reviews and meta-analysis will collect the evidence published about the ICU-AW.

Conclusion: We hope that our research will contribute to clinicians and public decision making about the ICU-AW.

Registration number: INPLASY202070067.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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