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Comment
. 2020 Nov 1;26(21):5546-5548.
doi: 10.1158/1078-0432.CCR-20-2751. Epub 2020 Aug 26.

TRAIL and Cancer Immunotherapy: Take a Walk on the Short Side

Diego de Miguel  1 , Julian Pardo  2   3   4   5
Affiliations
Comment

TRAIL and Cancer Immunotherapy: Take a Walk on the Short Side

Diego de Miguel et al. Clin Cancer Res. .

Abstract

Recent work shows that TRAILshort, a membrane-bound short form of TRAIL, is expressed by human cancer cells and protects them from TRAIL-induced cell death. A mAb that selectively targets TRAILshort enhances cancer susceptibility to TRAIL and increases the efficacy of autologous CD8+ T cells in ex vivo primary tumors.See related article by Aboulnasr et al., p. 5759.

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References

    1. Aboulnasr F, Krogman A, Graham RP, Cummins NW, Misra A, Garcia-Rivera E, et al. Human cancers express TRAILshort, a dominant negative TRAIL splice variant, which impairs immune effector cell killing of tumor cells. Clin Cancer Res. 2020;26:5759–71.
    1. Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999;5:157–63.
    1. de Miguel D, Lemke J, Anel A, Walczak H, Martinez-Lostao L. Onto better TRAILs for cancer treatment. Cell Death Differ. 2016;4:174.
    1. Nie Z, Aboulnasr F, Natesampillai S, Burke SP, Krogman A, Bren GD, et al. Both HIV-infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment. J Immunol. 2018;200:1110–23.
    1. Martinez-Lostao L, Anel A, Pardo J. How do cytotoxic lymphocytes kill cancer cells?. Clin Cancer Res. 2015;21:5047–56.

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