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Comment
. 2020 Aug 26;11(1):4274.
doi: 10.1038/s41467-020-18194-1.

Fasting-mimicking diet plus chemotherapy in breast cancer treatment

Affiliations
Comment

Fasting-mimicking diet plus chemotherapy in breast cancer treatment

Claudio Vernieri et al. Nat Commun. .

Abstract

A clinical trial published in Nature Communications examined the effect of fasting-mimicking diet (FMD) during chemotherapy in breast cancer patients. The overall negative study results highlight the need for ameliorating future trial design and investigating alternative FMD-based therapeutic combinations.

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Conflict of interest statement

C.V., L.R. and F.deB. were inventors of an FMD regimen that is being evaluated in the context of ongoing clinical trials in cancer patients.

Comment on

References

    1. de Groot S, et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat. Commun. 2020;11:3083. doi: 10.1038/s41467-020-16138-3. - DOI - PMC - PubMed
    1. Di Biase S, et al. Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity. Cancer Cell. 2016;30:136–146. doi: 10.1016/j.ccell.2016.06.005. - DOI - PMC - PubMed
    1. Caffa I, et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020;583:620–624. doi: 10.1038/s41586-020-2502-7. - DOI - PMC - PubMed
    1. Brandhorst S, et al. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metab. 2015;22:86–99. doi: 10.1016/j.cmet.2015.05.012. - DOI - PMC - PubMed
    1. Raffaghello L, et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc. Natl Acad. Sci. USA. 2008;105:8215–8220. doi: 10.1073/pnas.0708100105. - DOI - PMC - PubMed

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