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. 2020 Aug 26;11(1):4253.
doi: 10.1038/s41467-020-17907-w.

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

S G P Funnell  1 , W E Dowling  2 , C Muñoz-Fontela  3 , P-S Gsell  4 , D E Ingber  5 , G A Hamilton  6 , L Delang  7 , J Rocha-Pereira  7 , S Kaptein  7 , K H Dallmeier  7 , J Neyts  7 , K Rosenke  8 , E de Wit  8 , H Feldmann  8 , P Maisonnasse  9 , R Le Grand  9 , M B Frieman  10 , C M Coleman  11
Affiliations

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

S G P Funnell et al. Nat Commun. .

Abstract

There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This commentary highlights an extraordinary international collaborative effort of independent researchers who have recently all come to the same conclusion—that chloroquine or hydroxchloroquine are unlikely to provide clinical benefit against COVID-19.

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Conflict of interest statement

D.E.I. holds equity and chairs the Scientific Advisory Board of Emulate Inc. G.A.H. holds equity and is an employee of Emulate Inc.

References

    1. Osada N, et al. The genome landscape of the african green monkey kidney-derived vero cell line. DNA Res. 2014. 2014;21:673–683. - PMC - PubMed
    1. Benam KH, et al. Small airway on a chip enables analysis of human lung inflammation and therapeutic responses in vivo. Nat. Methods. 2016;13:151–157. doi: 10.1038/nmeth.3697. - DOI - PubMed
    1. Benam KH, et al. Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip. Cell Syst. 2016;3:456–466. doi: 10.1016/j.cels.2016.10.003. - DOI - PubMed
    1. Nicolas de Lamballerie C, et al. Characterization of cellular transcriptomic signatures induced by different respiratory viruses in human reconstituted airway epithelia. Sci. Rep. 2019;9:11493. doi: 10.1038/s41598-019-48013-7. - DOI - PMC - PubMed
    1. Si, L. et al. Human organs-on-chips as tools for repurposing approved drugs as potential influenzae and COVID-19 therapeutics in viral pandemics. 10.1101/2020.04.13.039917 (2020).

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