Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec;16(12):705-706.
doi: 10.1038/s41581-020-00349-4.

CKD is a key risk factor for COVID-19 mortality

Ron T Gansevoort  1 , Luuk B Hilbrands  2
Affiliations

CKD is a key risk factor for COVID-19 mortality

Ron T Gansevoort et al. Nat Rev Nephrol. 2020 Dec.

Abstract

A new study uses the OpenSAFELY health analytics platform to identify risk factors for COVID-19 mortality. This analysis, which includes data for more than 17 million people in the UK, suggests that patients with chronic kidney disease are at higher risk than those with other known risk factors, including chronic heart and lung disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Risk factors for COVID-19-related deaths identified using the OpenSAFELY database.
Estimated hazard ratios (HRs) from a multivariable model. Error bars represent 95% confidence intervals. All HRs are adjusted for all other factors. Well-controlled diabetes is defined as HbA1c < 58 mmol/mol; not well controlled diabetes is defined as HbA1c ≥ 58 mmol/mol. CKD, chronic kidney disease; CVD, cardiovascular disease; CI, confidence interval; OCS, oral corticosteroids. Data obtained and figure adapted from ref., Springer Nature Limited.
See this image and copyright information in PMC

References

    1. Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. Guan WJ, et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur. Respir. J. 2020;55:2000547. doi: 10.1183/13993003.00547-2020. - DOI - PMC - PubMed
    1. Grasselli G, et al. Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA Intern. Med. 2020 doi: 10.1001/jamainternmed.2020. - DOI - PMC - PubMed
    1. Docherty AB, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. Br. Med. J. 2020;369:m1985. doi: 10.1136/bmj.m1985. - DOI - PMC - PubMed
    1. Kim L, et al. Risk factors for intensive care unit admission and in-hospital mortality among hospitalized adults identified through the U.S. Coronavirus Disease 2019 (COVID-19)-associated Hospitalization Surveillance Network (COVID-NET) Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1012. - DOI - PMC - PubMed