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. 2020 Oct;11(5):286-293.
doi: 10.14740/cr1121. Epub 2020 Aug 1.

Blood Plasma Resistin and Atrial Fibrillation in Patients With Cardiovascular Disease

George Samanidis  1   2 , Anastasios Gkogkos  1 , Stefanos Bousounis  1 , Leonidas Alexopoulos  3 , Despina N Perrea  1 , Konstantinos Perreas  2
Affiliations

Blood Plasma Resistin and Atrial Fibrillation in Patients With Cardiovascular Disease

George Samanidis et al. Cardiol Res. 2020 Oct.

Abstract

Background: Atrial fibrillation (AF) affects quality of life and prognosis of patients with cardiovascular disease. Resistin plays an important role in inflammatory response to internal and external factors. The aim of this study is to evaluate the association between resistin and permanent AF (PAF) in patients with cardiovascular disease.

Methods: In our study, we included 146 patients with cardiovascular disease. Plasma resistin concentrations and demographic characteristics of patients were recorded. The patients were divided in two groups: 118 patients without a history of PAF (NonAF group), and 28 patients with a history of PAF (AF group). Association of resistin with PAF and other variables was examined by parametric and non-parametric tests, and multivariable linear and univariable logistic regression analysis.

Results: No differences of demographic characteristics (gender, age and body mass index (BMI)) between two groups were observed (P > 0.05). Higher median levels of resistin were observed in group AF than in group NonAF (6.90 ng/mL vs. 5.83 ng/mL, P = 0.03). Multivariate linear regression analysis (adjusted to gender, age, BMI, hypertension, diabetes mellitus, coronary artery disease, and mitral valve disease) showed that resistin was associated with PAF (β = 0.79, 95% confidence interval (CI): 0.08 to 1.51, P = 0.03).

Conclusions: Our analysis showed that plasma resistin was associated with PAF, and resistin concentration was higher in patients with AF compared to those without AF.

Keywords: Atrial fibrillation; Cardiovascular disease; Resistin.

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Conflict of interest statement

None to declare.

Figures

Figure 1
Figure 1
Boxplot graph for the levels of resistin in the blood plasma of patients with and without permanent atrial fibrillation.
Figure 2
Figure 2
Boxplot graph for the levels of resistin in the blood plasma of patients with and without permanent atrial fibrillation depending to diabetes mellitus.
Figure 3
Figure 3
Association of resistin with body mass index (BMI) with 95% confidence interval (CI) (β = 0.001, 95% CI: -0.06 to 0.05, P = 0.78).
Figure 4
Figure 4
Association of resistin with left ventricular ejection fraction (LVEF) with 95% confidence interval (CI) (β = -0.01, 95% CI: -0.04 to 0.01, P = 0.37).
See this image and copyright information in PMC

References

    1. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M. et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016;37(38):2893–2962. doi: 10.1093/eurheartj/ehw210. - DOI - PubMed
    1. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, Conti JB. et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014;130(23):e199–267. - PMC - PubMed
    1. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR. et al. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307–312. doi: 10.1038/35053000. - DOI - PubMed
    1. Gomez-Ambrosi J, Fruhbeck G. Evidence for the involvement of resistin in inflammation and cardiovascular disease. Curr Diabetes Rev. 2005;1(3):227–234. doi: 10.2174/157339905774574392. - DOI - PubMed
    1. Bakker MF, Cavet G, Jacobs JW, Bijlsma JW, Haney DJ, Shen Y, Hesterberg LK. et al. Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study. Ann Rheum Dis. 2012;71(10):1692–1697. doi: 10.1136/annrheumdis-2011-200963. - DOI - PMC - PubMed

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