Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jul 31:10:1199.
doi: 10.3389/fonc.2020.01199. eCollection 2020.

A Multiple Primary Malignancy Patient With FANCA Gene Mutation: A Case Report and Literature Review

Qing Xia  1 , Ling-Yi Zhao  1   2 , Yi-Dan Yan  3 , Yuan Liao  4 , Ying-San Di  5 , Xiu-Ying Xiao  1
Affiliations
Case Reports

A Multiple Primary Malignancy Patient With FANCA Gene Mutation: A Case Report and Literature Review

Qing Xia et al. Front Oncol. .

Abstract

Background: Multiple primary malignancies (MPMs) refer to two or more primary malignant tumors in the same individual, the prevalence of which ranges from 0. 734 to 11.7%. The risk factors for MPMs vary and include both genetic and environmental causes. FANCA gene mutation might be a predisposition to the development of a second primary cancer. Here, we report a case in which a patient with a FANCA mutation developed thyroid papillary carcinoma and gastric adenocarcinoma. Case Presentation: A 48-year-old woman was diagnosed with thyroid cancer underwent resection in 2006. In 2008, the patient developed gastric adenocarcinoma and underwent radical gastrectomy. Gastric cancer was completely remitted after radiochemotherapy, but metastasis developed, and she received immunotherapy. The patient died on October 27, 2019. Peripheral blood gene detection showed germline FANCA mutation. Conclusions: Gene detection is of great importance in cancer patients, especially in those with MPMs. FANCA mutation is a predisposition to tumorigenesis that can increase the risk of developing MPMs. Patients with heterozygous FANCA gene mutations have poorer outcomes.

Keywords: FANCA gene; case report; gastric cancer; literature review; multiple primary malignancy; thyroid cancer.

PubMed Disclaimer

References

    1. Lv M, Zhang X, Shen Y, Wang F, Yang J, Wang B, et al. . Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors. Medicine. (2017) 96:e6799. 10.1097/MD.0000000000006799 - DOI - PMC - PubMed
    1. Gokyer A, Kostek O, Hacioglu MB, Erdogan B, Kodaz H, Turkmen E, et al. . Clinical features of the patient with multiple primary tumors: single center experience. North Clin Istanb. (2017) 4:43–51. 10.14744/nci.2017.67044 - DOI - PMC - PubMed
    1. Muto Y, Suzuki K, Kato T, Ichida K, Takayama Y, Fukui T, et al. . Multiple primary malignancies of six organs in a Japanese male patient: a case report. Mol Clin Oncol. (2019) 10:511–5. 10.3892/mco.2019.1819 - DOI - PMC - PubMed
    1. Adeyanju MA, Ilori AA. Multiple primary tumors. Niger J Clin Pract. (2017) 20:1346–9. 10.4103/njcp.njcp_432_16 - DOI - PubMed
    1. Jiao F, Yao LJ, Zhou J, Hu H, Wang LW. Clinical features of multiple primary malignancies: a retrospective analysis of 72 Chinese patients. Asian Pac J Cancer Prev. (2014) 15:331–4. 10.7314/apjcp.2014.15.1.331 - DOI - PubMed

Publication types