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. 2021 Feb;60(1):545-548.
doi: 10.1007/s00394-020-02372-4. Epub 2020 Aug 26.

Vitamin D and COVID-19 infection and mortality in UK Biobank

Claire E Hastie  1 , Jill P Pell #  2 , Naveed Sattar #  3
Affiliations

Vitamin D and COVID-19 infection and mortality in UK Biobank

Claire E Hastie et al. Eur J Nutr. 2021 Feb.

Abstract

Purpose: Low blood 25-hydroxyvitamin D (25(OH)D) concentration has been proposed as a potential causal factor in COVID-19 risk. We aimed to establish whether baseline serum 25(OH)D concentration was associated with COVID-19 mortality, and inpatient confirmed COVID-19 infection, in UK Biobank participants.

Methods: UK Biobank recruited 502,624 participants aged 37-73 years between 2006 and 2010. Baseline exposure data, including serum 25(OH)D concentration, were linked to COVID-19 mortality. Univariable and multivariable Cox proportional hazards regression analyses were performed for the association between 25(OH)D and COVID-19 death, and Poisson regression analyses for the association between 25(OH)D and severe COVID-19 infection.

Results: Complete data were available for 341,484 UK Biobank participants, of which 656 had inpatient confirmed COVID-19 infection and 203 died of COVID-19 infection. 25(OH)D concentration was associated with severe COVID-19 infection and mortality univariably (mortality per 10 nmol/L 25(OH)D HR 0.92; 95% CI 0.86-0.98; p = 0.016), but not after adjustment for confounders (mortality per 10 nmol/L 25(OH)D HR 0.98; 95% CI = 0.91-1.06; p = 0.696). Vitamin D insufficiency or deficiency was also not independently associated with either COVID-19 infection or linked mortality.

Conclusions: Our findings do not support a potential link between 25(OH)D concentrations and risk of severe COVID-19 infection and mortality. Randomised trials are needed to prove a beneficial role for vitamin D in the prevention of severe COVID-19 reactions or death.

Keywords: COVID-19; Mortality; Vitamin D.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Comment in

References

    1. Mitchell F. Vitamin-D and COVID-19: do deficient risk a poorer outcome? Lancet Diabetes Endocrinol. 2020;8:570. doi: 10.1016/S2213-8587(20)30183-2. - DOI - PMC - PubMed
    1. Sattar N, Welsh P, Panarelli M, Forouhi NG. Increasing requests for vitamin D measurement: costly, confusing, and without credibility. Lancet. 2012;379:95–96. doi: 10.1016/S0140-6736(11)61816-3. - DOI - PubMed
    1. The Centre for Evidence-Based Medicine. (2020) Vitamin D: a rapid review of the evidence for treatment or prevention in COVID-19. https://www.cebm.net/covid-19/vitamin-d-a-rapid-review-of-the-evidence-f.... Accessed 26 Jun 2020
    1. NICE. COVID-19 rapid evidence summary:vitamin D for COVID-19. https://www.nice.org.uk/advice/es28/evidence. Accessed 11 Aug 2020.
    1. (2020) Welsh Government. COVID-19 workforce risk assessment tool. https://gov.wales/checkyourrisk. Accessed 11 Aug 2020