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. 2020 Oct;140(4):583-586.
doi: 10.1007/s00401-020-02213-y. Epub 2020 Aug 26.

Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology

Nikolaus Deigendesch  1 , Lara Sironi  1 , Michael Kutza  2 , Sven Wischnewski  2 , Vidmante Fuchs  3 , Jürgen Hench  1 , Angela Frank  4 , Ronny Nienhold  4 , Kirsten D Mertz  4 , Gieri Cathomas  4 , Matthias S Matter  1 , Martin Siegemund  5   6 , Markus Tolnay  1 , Lucas Schirmer  2 , Anne-Katrin Pröbstel  3 , Alexandar Tzankov  1 , Stephan Frank  7
Affiliations

Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology

Nikolaus Deigendesch et al. Acta Neuropathol. 2020 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
Microglia and astroglia activation in the pons. a–c Activation of microglia (stained for HLA-DR) and astrocytes (stained for GFAP). Representative sample of the COVID-19 cohort (a, case 4), a control with fungal sepsis and systemic inflammation (b, case 10), and a non-septic control (c, case 15). Histology image frame colors indicate individual case data points in the quantitative analysis below. d Automated quantification of HLA-DR immunopositive areas in the pons, medulla oblongata, and olfactory bulb. Each data point represents the mean of six crack artifact-free areas per slide and case of the COVID-19 cohort compared to controls. SARS-CoV-2 positive cases represented by triangles. Scale bars represent 100 μm unless otherwise indicated
See this image and copyright information in PMC

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