Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan 1;26(1):e90-e96.
doi: 10.4317/medoral.24023.

Intraoral soft tissue lipomas: clinicopathological features from 91 cases diagnosed in a single Oral Pathology service

F-R Pires  1 , L Souza, R Arruda, M-H Cantisano, B-L Picciani, T-C Dos Santos
Affiliations

Intraoral soft tissue lipomas: clinicopathological features from 91 cases diagnosed in a single Oral Pathology service

F-R Pires et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: intraoral soft tissue lipomas are relatively uncommon mesenchymal neoplasms. Few papers have been published comparing the clinicopathological features of these tumors in different populations. The aim of the present study was to analyze the clinicopathological features from intraoral soft tissue lipomas diagnosed in a Brazilian population.

Material and methods: all cases diagnosed as intraoral soft tissue lipomas in an Oral Pathology laboratory from 2005 to 2019 were retrieved and descriptively analyzed; statistical analysis was performed for comparison of the clinical and demographic parameters.

Results: 91 intraoral lipomas were retrieved, including 56 lipomas, 30 fibrolipomas, 2 spindle cell lipomas, 2 angiolipomas, and 1 chondrolipoma. Mean age of the patients was 62.2 years and females represented 57.1% of the sample. Mean time of complaint was 45.4 months and mean size of the lesions was 16.2 millimeters. Buccal mucosa (38.8%), lower lip (18.8%) and tongue (16.5%) were the most commonly affected locations. Fibrolipomas were more common in females (p=0,037) and presented as smaller lesions (p=0,011) in comparison to lipomas.

Conclusions: report of clinicopathological data from intraoral lipomas aid in establishing their differential diagnostic criteria and clinical profile in this specific location.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Histological characteristics of intraoral lipomas. A. Conventional lipoma showing a monotonous proliferation of mature adipocytes (HE, 10x); B. Presence of mature adipocytes and a collagenous fibrous tissue in fibrolipoma (HE, 10x); C. Spindle cells and adipocytes in a spindle cell lipoma (HE, 40x); D. CD34-positive spindle cells in spindle cell lipoma (Immunoperoxidase, 40x); E. Adipose tissue associated to fibrin thrombi-containing small blood vessels in angiolipoma (HE, 10x); F. Mature chondroid tissue associated with adipose tissue in chondrolipoma (HE, 10x).
See this image and copyright information in PMC

References

    1. Epivatianos A, Markopoulos AK, Papanayotou P. Benign tumors of adipose tissue of the oral cavity: a clinicopathologic study of 13 cases. J Oral Maxillofac Surg. 2000;58:1113–7. - PubMed
    1. Said-Al-Naief N, Zahurullah FR, Sciubba JJ. Oral spindle cell lipoma. Ann Diagn Pathol. 2001;5:207–15. - PubMed
    1. Fregnani ER, Pires FR, Falzoni R, Lopes MA, Vargas PA. Lipomas of the oral cavity: clinical findings, histological classification and proliferative activity of 46 cases. Int J Oral Maxillofac Surg. 2003;32:49–53. - PubMed
    1. Furlong MA, Fanburg-Smith JC, Childers ELB. Lipoma of the oral and maxillofacial region: site and subclassification of 125 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:441–50. - PubMed
    1. Bandéca MC, de Pádua JM, Nadalin MR, Ozório JEV, Silva-Sousa YTC, Perez DEC. Oral soft tissue lipomas: a case series. J Can Dent Assoc. 2007;73:431–4. - PubMed