Microelectrode-Based Electrochemical Sensing Technology for in Vivo Detection of Dopamine: Recent Developments and Future Prospects
- PMID: 32852227
- DOI: 10.1080/10408347.2020.1811946
Microelectrode-Based Electrochemical Sensing Technology for in Vivo Detection of Dopamine: Recent Developments and Future Prospects
Abstract
Dopamine (DA) is an essential type of neurotransmitter in the central nervous system. DA neurons usually exist as nuclei which are mainly found in the ventral tegmental area (VTN) and substantia nigra pars compacta (SNc). Parkinson's disease, epilepsy, schizophrenia and other diseases are all related to the abnormal metabolism of DA. Compared with traditional DA detection methods such as spectrophotometry and electrophoresis, electrochemical sensing technology has high detection efficiency, high sensitivity, fast and convenient real-time detection, which is recognized as the most effective method for measuring neurotransmitters in vivo. The working electrode of an electrochemical sensor can be generally divided into the conventional electrode and the microelectrode according to its size. The microelectrode shows excellent properties such as high sensitivity, high temporal resolution, and high spatial resolution while detecting DA, which makes it possible to detect neurotransmitters in vivo. In order to further investigate the role of DA in regulating action, emotion, and cognition, and to further clarify the relationship between DA abnormalities or lack and neurological diseases such as Parkinson, more and more researchers apply microelectrode-based electrochemistry sensing technology to detect DA in vivo. This article reviews recent applications of microelectrodes and the latest researches in DA detection in vivo, focusing on the following three types of microelectrodes: (1) non-nanomaterial-modified carbon fiber microelectrodes (CFE); (2) nanomaterial-modified microelectrodes; (3) microelectrode arrays (MEA).
Keywords: Carbon fiber electrode; dopamine; microelectrode; microelectrode arrays; nanomaterial.
Similar articles
-
Direct in Vivo Electrochemical Detection of Resting Dopamine Using Poly(3,4-ethylenedioxythiophene)/Carbon Nanotube Functionalized Microelectrodes.Anal Chem. 2019 Oct 15;91(20):12917-12927. doi: 10.1021/acs.analchem.9b02904. Epub 2019 Sep 26. Anal Chem. 2019. PMID: 31512849 Free PMC article.
-
Carbon-fiber microelectrodes for in vivo applications.Analyst. 2009 Jan;134(1):18-24. doi: 10.1039/b807563h. Epub 2008 Oct 31. Analyst. 2009. PMID: 19082168 Free PMC article.
-
Electrochemical Sensing of Dopamine with an Implantable Microelectrode Array Microprobe Including an On-Probe Iridium Oxide Reference Electrode.ACS Chem Neurosci. 2025 Feb 19;16(4):642-648. doi: 10.1021/acschemneuro.4c00658. Epub 2025 Feb 5. ACS Chem Neurosci. 2025. PMID: 39909725
-
I. Serotonin (5-HT) within dopamine reward circuits signals open-field behavior. II. Basis for 5-HT--DA interaction in cocaine dysfunctional behavior.Neurosci Biobehav Rev. 1997 May;21(3):227-60. doi: 10.1016/s0149-7634(96)00048-6. Neurosci Biobehav Rev. 1997. PMID: 9168262 Review.
-
Graphene and Carbon Nanotube-based Electrochemical Sensing Platforms for Dopamine.Chem Asian J. 2021 Nov 15;16(22):3516-3543. doi: 10.1002/asia.202100898. Epub 2021 Sep 27. Chem Asian J. 2021. PMID: 34487610 Review.
Cited by
-
A versatile and ultrasensitive molecularly imprinted electrochemiluminescence sensor with HRP-encapsulated liposome labeled by light-triggered click reaction for pesticide residues.Mikrochim Acta. 2021 Dec 21;189(1):33. doi: 10.1007/s00604-021-05133-0. Mikrochim Acta. 2021. PMID: 34935073
-
An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection.Biosensors (Basel). 2023 Sep 19;13(9):892. doi: 10.3390/bios13090892. Biosensors (Basel). 2023. PMID: 37754127 Free PMC article. Review.
-
Detection of Dopamine Based on Aptamer-Modified Graphene Microelectrode.Sensors (Basel). 2024 May 5;24(9):2934. doi: 10.3390/s24092934. Sensors (Basel). 2024. PMID: 38733043 Free PMC article.
-
Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information.Nanomicro Lett. 2023 Dec 12;16(1):49. doi: 10.1007/s40820-023-01274-4. Nanomicro Lett. 2023. PMID: 38087121 Free PMC article. Review.
-
Gold Nanoclusters Dispersed on Gold Dendrite-Based Carbon Fibre Microelectrodes for the Sensitive Detection of Nitric Oxide in Human Serum.Biosensors (Basel). 2022 Dec 5;12(12):1128. doi: 10.3390/bios12121128. Biosensors (Basel). 2022. PMID: 36551095 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous