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. 2020 Dec;136(6):1109-1113.
doi: 10.1097/AOG.0000000000004128.

High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19)

Bijan Safaee Fakhr  1 , Steffen B Wiegand, Riccardo Pinciroli, Stefano Gianni, Caio C A Morais, Takamitsu Ikeda, Yusuke Miyazaki, Eizo Marutani, Raffaele Di Fenza, Grant M Larson, Vibhu Parcha, Lauren E Gibson, Marvin G Chang, Pankaj Arora, Ryan W Carroll, Robert M Kacmarek, Fumito Ichinose, William H Barth Jr, Anjali Kaimal, Elizabeth L Hohmann, Warren M Zapol, Lorenzo Berra
Affiliations

High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19)

Bijan Safaee Fakhr et al. Obstet Gynecol. 2020 Dec.

Abstract

Background: Rescue therapies to treat or prevent progression of coronavirus disease 2019 (COVID-19) hypoxic respiratory failure in pregnant patients are lacking.

Method: To treat pregnant patients meeting criteria for severe or critical COVID-19 with high-dose (160-200 ppm) nitric oxide by mask twice daily and report on their clinical response.

Experience: Six pregnant patients were admitted with severe or critical COVID-19 at Massachusetts General Hospital from April to June 2020 and received inhalational nitric oxide therapy. All patients tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A total of 39 treatments was administered. An improvement in cardiopulmonary function was observed after commencing nitric oxide gas, as evidenced by an increase in systemic oxygenation in each administration session among those with evidence of baseline hypoxemia and reduction of tachypnea in all patients in each session. Three patients delivered a total of four neonates during hospitalization. At 28-day follow-up, all three patients were home and their newborns were in good condition. Three of the six patients remain pregnant after hospital discharge. Five patients had two negative test results on nasopharyngeal swab for SARS-CoV-2 within 28 days from admission.

Conclusion: Nitric oxide at 160-200 ppm is easy to use, appears to be well tolerated, and might be of benefit in pregnant patients with COVID-19 with hypoxic respiratory failure.

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Figures

Fig. 1.
Fig. 1.. Clinical flow chart for nitric oxide therapy in pregnant patients with coronavirus disease 2019 (COVID-19) at Massachusetts General Hospital. COVID-19, coronavirus disease 2019; BID, twice a day; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; CRP, c-reactive protein; WBC, white blood cells; AST, aspartate aminotransferase; ALT, alanine aminotransferase; IL-6, interleukin-6; RT-PCR, real time reverse transcription polymerase chain reaction.
Safaee Fakhr. Nitric Oxide in Pregnant Patients With COVID-19. Obstet Gynecol 2020.
Fig. 2.
Fig. 2.. Nitric oxide delivery system. Schematic representation of the NO delivery system for spontaneous breathing patients. HEPA, high-efficiency particulate air. Modified from Gianni S, Safaee Fakhr B, Araujo Morais CC, Di Fenza R, Larson G, Pinciroli R, et al. Nitric oxide gas inhalation to prevent COVID-2019 in healthcare providers. Preprint. Posted online April 11, 2020. medRxiv. doi: 10.1101/2020.04.05.20054544. Used with permission of the author.
Safaee Fakhr. Nitric Oxide in Pregnant Patients With COVID-19. Obstet Gynecol 2020.
Figure
Figure
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