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Editorial
. 2020 Aug 28;127(6):824-826.
doi: 10.1161/CIRCRESAHA.120.317723. Epub 2020 Aug 27.

HDAC9: An Inflammatory Link in Atherosclerosis

Sadhan Das  1 , Rama Natarajan  1
Affiliations
Editorial

HDAC9: An Inflammatory Link in Atherosclerosis

Sadhan Das et al. Circ Res. .
No abstract available

Keywords: Editorials; atherosclerosis; inflammation; monocytes; stroke.

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Figures

Figure 1.
Figure 1.. HDAC9 actions in atherosclerosis.
HDAC9 risk alleles can increase HDAC9 expression. HDAC9 interacts with IKK kinases, leading to their deacetylation and activation. IKK phosphorylates and activates NF-κB p65 leading to increased inflammatory phenotypes in macrophages and endothelial cells associated with atherosclerosis and vulnerable plaque. HDAC9 deletion or pharmacological inhibition by TMP195 inhibits such inflammatory phenotypes and ameliorates atherosclerosis and enhances plaque stability in mice.
See this image and copyright information in PMC

Comment on

  • Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
    Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M. Asare Y, et al. Circ Res. 2020 Aug 28;127(6):811-823. doi: 10.1161/CIRCRESAHA.120.316743. Epub 2020 Jun 17. Circ Res. 2020. PMID: 32546048

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