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Comment
. 2021 Jan;82(1):e11-e14.
doi: 10.1016/j.jinf.2020.08.032. Epub 2020 Aug 25.

SARS-CoV-2 IgG and IgA antibody response is gender dependent; and IgG antibodies rapidly decline early on

Wolfgang Korte  1 , Marija Buljan  2 , Matthias Rösslein  2 , Peter Wick  2 , Valentina Golubov  3 , Jana Jentsch  3 , Michael Reut  3 , Karen Peier  4 , Brigitte Nohynek  5 , Aldo Fischer  5 , Raphael Stolz  5 , Michele Cettuzzi  5 , Oliver Nolte  6
Affiliations
Comment

SARS-CoV-2 IgG and IgA antibody response is gender dependent; and IgG antibodies rapidly decline early on

Wolfgang Korte et al. J Infect. 2021 Jan.
No abstract available

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Figures

Fig 1
Fig. 1
a-c: Overall (gender independent) course of anti-SARS-CoV-2 antibodies: a) anti-NC IgG; b) anti-SP IgG; c) anti-SP IgA. Local Polynomial Regression Fitting with 2 standard errors (dotted lines). Anti-NC IgG showed a significant increase (weeks 3 to 5) before a significant decline (weeks 8 to 10, all p < 0•0075, Wilcoxon test, 1a), as did anti-SP IgG (weeks 4 to 6 and weeks 8 to 10, all p< 0•012, 1b). Note the dichotomous IgA distribution, 1c.
Fig 2
Fig. 2
a-c: Sex specific course of anti-SARS-CoV-2 antibodies in females (green) and males (red): a) anti-NC IgG; b) anti-SP IgG; c) anti-SP IgA. Curves connect medians. Significant differences are seen weeks 6 - 7 (anti-NC IgG, all p<0•0054, Wilcoxon test, Fig. 2a); weeks 4 - 5 (anti-SP IgG, all p < 0•0004, Fig. 2b); and weeks 4 - 7 (anti-SP IgA, all p < 0•0095, Fig. 2c). Samples from predominantly male (77% of samples with OI > 20, p < 0•01, Fisher's exact test) patients with very high, dichotomically separated IgA antibody values were seen (inset 2c, see also 1c). Dotted lines separate increased (reactive) from non-increased antibody concentrations.
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Comment on

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