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. 2020;43(11):613-619.
doi: 10.1159/000509519. Epub 2020 Aug 27.

Prognosis of Patients with Metastatic Soft Tissue Sarcoma: Advances in Recent Years

Jakob Lochner  1 , Franka Menge  1 , Nikolaos Vassos  1 , Peter Hohenberger  1 , Bernd Kasper  2
Affiliations

Prognosis of Patients with Metastatic Soft Tissue Sarcoma: Advances in Recent Years

Jakob Lochner et al. Oncol Res Treat. 2020.

Abstract

Objective: The objective of this study was to investigate the prognosis of patients with metastatic soft tissue sarcomas (STS) and to define prognostic indicators for overall survival (OS).

Methods: All patients who were treated at the Sarcoma Unit at the Mannheim University Medical Center between 2010 and 2016 and who developed metastatic disease deriving from a STS were included in this retrospective analysis. OS was investigated using data from clinical records and German registry offices. Clinical and pathological characteristics were recorded and analyzed.

Results: A total number of 212 patients developed metastatic disease from STS during that period. Median OS after first documentation of metastatic disease was 24 months (95% CI 21-33). 1-, 2-, and 5-year OS rates were 70.0% (95% CI 64-77), 49.9% (95% CI 43-58), and 24.8% (95% CI 19-33), respectively. In multivariate analysis, significant predictors for mortality appeared to be gender, age, location and size of the primary tumor, histology, and disease-free interval.

Conclusion: Being treated in a high-volume STS reference center in Germany, patients with metastatic disease could demonstrate an increased OS compared to former analyses. These data can be used as a benchmark for upcoming studies and highlight that further research on treatment strategies in this rare disease is urgently needed.

Keywords: Metastasis; Overall survival; Prognosis; Prognostic factors; Soft tissue sarcoma.

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