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Review
. 2021 Mar:46:100742.
doi: 10.1016/j.blre.2020.100742. Epub 2020 Aug 13.

Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?

Hamdan Hamdan  1 , Shahrukh K Hashmi  2 , Hillard Lazarus  3 , Robert Peter Gale  4 , Wenchun Qu  5 , Riad El Fakih  6
Affiliations
Review

Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?

Hamdan Hamdan et al. Blood Rev. 2021 Mar.

Abstract

Mesenchymal stromal cells (MSC) have immune regulatory and tissue regenerative properties. MSCs are being studied as a therapy option for many inflammatory and immune disorders and are approved to treat acute graft-versus-host disease (GvHD). The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic and associated coronavirus infectious disease-19 (COVID-19) has claimed many lives. Innovative therapies are needed. Preliminary data using MSCs in the setting of acute respiratory distress syndrome (ARDS) in COVID-19 are emerging. We review mechanisms of action of MSCs in inflammatory and immune conditions and discuss a potential role in persons with COVID-19.

Keywords: COVID-19; Mesenchymal stromal cell; SARS-CoV2.

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Conflict of interest statement

None.

cells.

Figures

Fig. 1
Fig. 1
Schematic overview of the complex interactions between MSCs and immune.
See this image and copyright information in PMC

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