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Comment
. 2020 Oct;10(10):1435.
doi: 10.1158/2159-8290.CD-NB2020-076. Epub 2020 Aug 27.

Precision Medicine Stumbles in Umbrella Trial

No authors listed
Comment

Precision Medicine Stumbles in Umbrella Trial

No authors listed. Cancer Discov. 2020 Oct.

Abstract

The National Lung Matrix Trial, an umbrella trial of targeted therapies in non-small cell lung cancer, revealed that most drugs prescribed based on specific genomic aberrations showed little efficacy, but new approaches could bolster precision medicine.

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  • The National Lung Matrix Trial of personalized therapy in lung cancer.
    Middleton G, Fletcher P, Popat S, Savage J, Summers Y, Greystoke A, Gilligan D, Cave J, O'Rourke N, Brewster A, Toy E, Spicer J, Jain P, Dangoor A, Mackean M, Forster M, Farley A, Wherton D, Mehmi M, Sharpe R, Mills TC, Cerone MA, Yap TA, Watkins TBK, Lim E, Swanton C, Billingham L. Middleton G, et al. Nature. 2020 Jul;583(7818):807-812. doi: 10.1038/s41586-020-2481-8. Epub 2020 Jul 15. Nature. 2020. PMID: 32669708 Free PMC article. Clinical Trial.

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