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. 2021 May 1;106(5):1476-1479.
doi: 10.3324/haematol.2020.267047.

How to implement endurance exercise training in sickle cell disease

Laurent A Messonnier  1 , Manon Riccetti  1 , Benjamin Chatel  2 , Frédéric Galactéros  3 , Barnabas Gellen  4 , Thomas Rupp  1 , Léonard Féasson  5 , Pablo Bartolucci  3
Affiliations

How to implement endurance exercise training in sickle cell disease

Laurent A Messonnier et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Relationship between blood lactate concentration and heart rate in 15 patients with sickle cell disease during exercise. The relationship between blood lactate concentration ([lactate]b) versus heart rate (HR) relationship during a first submaximal incremental test (black circles) and a second one for two patients (gray circles, panels N and O), as well as the [lactate]b–HR pairs measured during the training sessions (open triangles). HR at the first lactate threshold (LT1) as well as at 2.5 mmol.L-1 are also reported (vertical dotted lines).
Figure 2.
Figure 2.
Relationship between blood lactate concentration, rating of perceived exertion and heart rate in 15 patients with sickle cell disease during exercise. The relationship between blood lactate concentration ([lactate]b) versus heart rate (HR) relationship during a first submaximal incremental test (black circles) or a second one for two patients (gray circles, panels N and O), as well as the rating of perceived exertion (RPE) values obtained during the same trials (open squares). HR at the first lactate threshold (LT1) as well as at 2.5 mmol.L-1 are also reported (vertical dotted lines).
See this image and copyright information in PMC

References

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    1. Gellen B, Messonnier LA, Galacteros F, et al. . Moderate-intensity endurance-exercise training in patients with sickle-cell disease without severe chronic complications (exdre): An open-label randomised controlled trial. Lancet Haematol. 2018;5(11):e554-e562. - PubMed
    1. Merlet AN, Messonnier LA, Coudy-Gandilhon C, et al. . Beneficial effects of endurance exercise training on skeletal muscle microvasculature in sickle cell disease patients. Blood. 2019;134(25):2233-2241. - PubMed
    1. Messonnier LA, Gellen B, Lacroix R, et al. . Physiological evaluation for endurance exercise prescription in sickle cell disease. Med Sci Sports Exerc. 2019;51(9):1795-1801. - PubMed
    1. Chatel B, Messonnier LA, Bendahan D. Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease? Exp Physiol. 2018;103(9):1213-1220. - PubMed

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