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. 2020 Aug 28;12(16):15938-15945.
doi: 10.18632/aging.103632. Epub 2020 Aug 28.

Clinical characteristics of chronic liver disease with coronavirus disease 2019 (COVID-19): a cohort study in Wuhan, China

Chaowei Li  1 , Qingshi Chen  2 , Jianwen Wang  3 , Huasong Lin  4 , Yalan Lin  5 , Jinhuang Lin  6 , Fangzhan Peng  7 , Jiangmu Chen  1 , Zhirong Yang  8
Affiliations

Clinical characteristics of chronic liver disease with coronavirus disease 2019 (COVID-19): a cohort study in Wuhan, China

Chaowei Li et al. Aging (Albany NY). .

Abstract

Background: Previous work has described acute liver injury (ALI) in coronavirus disease 2019 (COVID-19) pneumonia patients, However, there is limited analyses available investigating chronic liver disease (CLD) in COVID-19 patients. This study aimed to investigate clinical characteristics and outcomes of CLD confirmed in COVID-19 patients.

Results: A total of 104 cases (each group containing 52 patients) were analyzed in this study. The CLD group showed an average of 14 (10.0~21.2) length of stay (LOS) days, compared to the group without CLD that only showed an average of 12.5 (10~16) LOS days (Relative Risk [RR] = 1.34, 95% CI (1.22~1.48), P<0.001; Adjusted Relative Risk was 1.24 (95% CI: 1.12~1.39)). The CLD group contained a higher mortality rate and slight liver injury. Furthermore, COX regression model analyses suggested that the neutrophil-to-lymphocyte ratio (NLR) was an independent predictor of mortality risk (P < 0.001) in the CLD group. Additionally, a high NLR significantly correlated with a shorter overall survival (P <0.001).

Conclusions: COVID-19 patients also diagnosed with CLD suffered longer LOS, slight liver injuries and a higher mortality when compared to COVID-19 patients without CLD. The NLR was an independent risk factor for in-hospital deaths. Increased expression of NLR was an indicator of poor prognosis in COVID-19 patients with CLD. Thus, COVID-19 patients diagnosed with CLD and who show a higher NLR need additional care.

Methods: A retrospective cohort study was performed at the Wuhan Jin Yin-tan Hospital from February 2, 2020 to April 2, 2020. COVID-19 patients diagnosed with CLD or not diagnosed with CLD were enrolled in this study. The clinical characteristics and outcomes of these patients were compared.

Keywords: COVID-19; LOS; NLR; mortality; severity.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors disclose no conflicts of interest.

Figures

Figure 1
Figure 1
Kaplan-Meier analysis of overall survival (OS) according to NLR expression in CLD with COVID-19 infection patients.
See this image and copyright information in PMC

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