Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug 31;46(4):220-227.
doi: 10.5125/jkaoms.2020.46.4.220.

Oral rehabilitation of Papillon-Lefèvre syndrome patients by dental implants: a systematic review

Fazele Atarbashi-Moghadam  1 , Saede Atarbashi-Moghadam  2 , Setare Kazemifard  3 , Soran Sijanivandi  3 , Mahshid Namdari  4   5
Affiliations
Review

Oral rehabilitation of Papillon-Lefèvre syndrome patients by dental implants: a systematic review

Fazele Atarbashi-Moghadam et al. J Korean Assoc Oral Maxillofac Surg. .

Abstract

Objectives: Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder. These patients lose their teeth at a young age and are in need of prosthetic rehabilitation. The aim of this systematic review was to assess the success of dental implant placement in these patients.

Materials and methods: An electronic search was performed in PubMed Central, Scopus, and Web of Science using the keyword "Papillon-Lefèvre syndrome" AND "dental implant" OR "prosthodontics". Articles reporting implant placement in patients with PLS until July 2019 were included.

Results: Assessment of the included 11 articles reporting 15 cases showed 136 implant placements in these patients. Implant failure occurred in 3 patients (20 implants). The peri-implantitis and failure rate was higher in the maxilla. Meta-analysis showed the probability of failure to be 7% (95% confidence interval [CI] 0%-31%) for maxillary implants and 2% (95% CI 0%-9%) for mandibular implants. The follow-up time ranged between 1 and 20 years. Healing after bone graft and implant placement in these patients was uneventful.

Conclusion: Dental implants may be a viable treatment option for PLS patients. Implantation can help preserve alveolar bone if the patients' immunological and growing conditions are well-considered and proper oral hygiene and compliance with the maintenance program are continued.

Keywords: Dental implants; Oral rehabilitation; Papillon–Lefèvre syndrome; Prosthodontics; Rapid progressive periodontitis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Diagram of literature search and selection criteria adapted from PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) . (PLS: Papillon–Lefèvre syndrome)
Fig. 2
Fig. 2
Probability of implant failure based on maxillary and mandibular implant. (ES: effect size, CI: confidence interval)
See this image and copyright information in PMC

References

    1. Bohner L, Hanisch M, Kleinheinz J, Jung S. Dental implants in growing patients: a systematic review. Br J Oral Maxillofac Surg. 2019;57:397–406. doi: 10.1016/j.bjoms.2019.04.011. doi: 10.1016/j.bjoms.2019.04.011. - DOI - DOI - PubMed
    1. Heuberer S, Dvorak G, Mayer C, Watzek G, Zechner W. Dental implants are a viable alternative for compensating oligodontia in adolescents. Clin Oral Implants Res. 2015;26:e22–7. doi: 10.1111/clr.12323. doi: 10.1111/clr.12323. - DOI - DOI - PubMed
    1. Toygar HU, Kircelli C, Firat E, Guzeldemir E. Combined therapy in a patient with Papillon-Lefèvre syndrome: a 13-year follow-up. J Periodontol. 2007;78:1819–24. doi: 10.1902/jop.2007.070004. doi: 10.1902/jop.2007.070004. - DOI - DOI - PubMed
    1. Machado RA, Cuadra-Zelaya FJM, Martelli-Júnior H, Miranda RT, Casarin RCV, Corrêa MG, et al. Clinical and molecular analysis in Papillon-Lefèvre syndrome. Am J Med Genet A. 2019;179:2124–31. doi: 10.1002/ajmg.a.61285. doi: 10.1002/ajmg.a.61285. - DOI - DOI - PubMed
    1. Hart TC, Shapira L. Papillon-Lefèvre syndrome. Periodontol 2000. 1994;6:88–100. doi: 10.1111/j.1600-0757.1994.tb00029.x. doi: 10.1111/j.1600-0757.1994.tb00029.x. - DOI - DOI - PubMed