Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Aug 27;5(1):173.
doi: 10.1038/s41392-020-00291-8.

Promising inhibitors targeting Mpro: an ideal strategy for anti-SARS-CoV-2 drug discovery

Yi Chen #  1 , Guan Wang #  1 , Liang Ouyang  2
Affiliations
Comment

Promising inhibitors targeting Mpro: an ideal strategy for anti-SARS-CoV-2 drug discovery

Yi Chen et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Design and discovery of drug candidates targeting Mpro against COVID-19
See this image and copyright information in PMC

Comment on

References

    1. Dai W, et al. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science. 2020;368:1331–1335. doi: 10.1126/science.abb4489. - DOI - PMC - PubMed
    1. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat. Microbiol. 2020;5:536–544. doi: 10.1038/s41564-020-0695-z. - DOI - PMC - PubMed
    1. Penman SL, et al. Safety perspectives on presently considered drugs for the treatment of COVID-19. Br. J. Pharmcol. 2020 doi: 10.1111/bph.15204. - DOI - PMC - PubMed
    1. Jin Z, et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020;582:289–293. doi: 10.1038/s41586-020-2223-y. - DOI - PubMed
    1. Pillaiyar T, et al. An overview of severe acute respiratory syndrome-coronavirus (SARS-CoV) 3CL protease inhibitors: peptidomimetics and small molecule chemotherapy. J. Med. Chem. 2016;59:6595–6628. doi: 10.1021/acs.jmedchem.5b01461. - DOI - PMC - PubMed

Publication types

Substances