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. 2020 Jun 17;5(1):143-174.
doi: 10.20411/pai.v5i1.365. eCollection 2020.

Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop

Dana Gabuzda  1 , Beth D Jamieson  2 , Ronald G Collman  3 , Michael M Lederman  4 , Tricia H Burdo  5 , Steven G Deeks  6 , Dirk P Dittmer  7 , Howard S Fox  8 , Nicholas T Funderburg  9 , Savita G Pahwa  10 , Ivona Pandrea  11 , Cara C Wilson  12 , Peter W Hunt  6
Affiliations

Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop

Dana Gabuzda et al. Pathog Immun. .

Abstract

People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff organized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.

Keywords: HIV; aging; cellular senescence; inflammaging; microbiome.

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Conflict of interest statement

Nicholas Funderberg serves as a consultant for Gilead. Michael M. Lederman is the senior editor for Pathogens and Immunity. Steven G. Deeks, Dirk P. Dittmer, Nicholas T. Funderburg, and Peter W. Hunt serve as associate editors for Pathogens and Immunity.

Figures

Figure 1.
Figure 1.
Venn diagram of three high priority topics for research on aging and age-related comorbidities in people with HIV on ART. These three topics were selected by the basic science working group of the HIV ACTION Workshop for presentations and discussion at the workshop. Five cross-cutting themes are shown outside the Venn diagram. Artwork courtesy of Dr. Leia Novak.
Figure 2.
Figure 2.
Venn diagram of drivers and mechanisms of aging in people with HIV on ART. These drivers and mechanisms of aging and their relationship to age-related comorbidities and the discovery of potential therapeutic targets in people with HIV were topics highlighted at the HIV ACTION workshop. Modified from artwork courtesy of Dr. Leia Novak. Abbreviations: ART, antiretroviral therapy; PrEP, pre-exposure prophylaxis.
See this image and copyright information in PMC

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