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Review
. 2021 Mar;31(2):e2159.
doi: 10.1002/rmv.2159. Epub 2020 Aug 28.

Vitamin D and Covid-19: From potential therapeutic effects to unanswered questions

Majid Teymoori-Rad  1 , Sayed Mahdi Marashi  1
Affiliations
Review

Vitamin D and Covid-19: From potential therapeutic effects to unanswered questions

Majid Teymoori-Rad et al. Rev Med Virol. 2021 Mar.

Abstract

Evidence suggests that vitamin D supplementation could potentially be effective either in treatment or prevention of coronavirus disease 2019 (Covid-19). Indeed, several studies and trials have begun to investigate the impact of vitamin D supplementation on patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we focus on the potential mechanisms of vitamin D in the pathogenesis of Covid-19. We consider whether deficiency of vitamin D may be one of the underlying biological factors that could explain the excess mortality seen among non-Caucasians. We also raise several important questions which need to be addressed to provide a clear picture of the extent to which vitamin D supplementation may benefit patients with Covid-19, particularly those with underlying risk factors.

Keywords: COVID-19; Vitamin D; immune response.

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Comment in

  • Coronavirus disease 2019 as a syndemic.
    Paul G. Paul G. Rev Med Virol. 2021 Jan;31(1):e2212. doi: 10.1002/rmv.2212. Epub 2021 Jan 19. Rev Med Virol. 2021. PMID: 33470019 Free PMC article. No abstract available.

References

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