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Meta-Analysis
. 2020 Nov;30(6):1-10.
doi: 10.1002/rmv.2121. Epub 2020 Aug 28.

The association between dengue viremia kinetics and dengue severity: A systemic review and meta-analysis

Sara Morsy  1   2 , Mohammad Rashidul Hashan  2   3 , Truong Hong Hieu  2   4 , Abdelrahman Tarek Mohammed  2   5 , Sameh Samir Elawady  2   6 , Prithwish Ghosh  2   7 , Manal A Elgendy  2   8 , Huu-Hoai Le  2   9 , Walid Mohamed Attiah Hamad  2   10 , Somia Iqtadar  2   11 , Shyam Prakash Dumre  12 , Kenji Hirayama  13 , Nguyen Tien Huy  13   14
Affiliations
Meta-Analysis

The association between dengue viremia kinetics and dengue severity: A systemic review and meta-analysis

Sara Morsy et al. Rev Med Virol. 2020 Nov.

Abstract

In this study, we aim to assess the association of dengue viremia with dengue severity. The study protocol was developed and registered in PROSPERO (CRD42016039864). We searched nine databases to find potential papers. Studies meeting the inclusion criteria were included. We, based our analysis on three outcomes which are disease severity, dengue serotype and disease infection type. Thirty studies with 3316 patients were included. Our analysis revealed that viremia is significantly higher in dengue hemorrhagic fever patients than dengue fever in days 5 to 6. Regarding the serotype of dengue, the maximum viremia titre of serotype 1 was significantly higher than serotype 3 and the viremia in dengue serotype 2 was significantly higher than serotype 4 in days 2 to 4. However, comparison of the daily viremia level between the primary and secondary dengue infection revealed that secondary infection was significantly higher than the primary infection on seventh day and on the eighth day. Viremia is strongly associated with disease severity and type of infection which gave viremia a high indicative power to be used as a clinical predictor. Dengue serotype is also associated with viral load with higher viremia in DENV-2/1.

Keywords: Viremia; dengue; meta-analysis; severity; systematic review; viral load.

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References

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