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. 2020 Nov;10(11):1255-1257.
doi: 10.1002/alr.22692. Epub 2020 Sep 29.

Does phenotypic expression of bitter taste receptor T2R38 show association with COVID-19 severity?

Henry P Barham  1   2 , Mohamed A Taha  1   3 , Christian A Hall  1   2
Affiliations

Does phenotypic expression of bitter taste receptor T2R38 show association with COVID-19 severity?

Henry P Barham et al. Int Forum Allergy Rhinol. 2020 Nov.

Abstract

Background: Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) has been identified as the pathogen causing the outbreak of coronavirus disease-2019 (COVID-19) commencing in Wuhan, China, in December 2019. Multiple reports have shown subjective loss of taste and smell as an early and hallmark symptom for COVID-19.

Methods: A retrospective study was performed in our clinical practice during July 2020 on patients positive for SARS-CoV-2 via polymerase chain reaction. All patients were categorized into 3 groups (supertasters, tasters, and nontasters) via taste sensitivity to phenylthiocarbamide, thiourea, and sodium benzoate with taste strip testing. The results of the taste strip tests were correlated with clinical course.

Results: A total of 100 patients (mean, 51 [range, 24-82] years of age; 44 [44%] women) were assessed. We found that 21 of 100 (21%) were nontasters, 79 of 100 (79%) were tasters, and 0 of 100 (0%) were supertasters (p < 0.001). Twenty-one of 21 (100%) (p < 0.001) of the patients requiring inpatient admission were classified as nontasters. All 79 (100%) (p < 0.001) of the patients who displayed mild to moderate symptoms not requiring admission were classified as tasters.

Conclusion: Our results show objective data that taste disturbance, specifically global loss of taste, appears to correlate with the clinical course specific to each individual, because 100% of the patients requiring inpatient admission were classified as nontasters.

Keywords: COVID, SARS-CoV-2; bitter taste receptors; solitary chemosensory cells.

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Figures

FIGURE 1
FIGURE 1
Association of taster status in cohort of positive severe acute respiratory syndrome‒associated coronavirus‐2 RNA using polymerase chain reaction. COVID‐19 = coronavirus disease‐2019.
See this image and copyright information in PMC

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