Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 9;222(11):1772-1775.
doi: 10.1093/infdis/jiaa523.

Are Seroprevalence Estimates for Severe Acute Respiratory Syndrome Coronavirus 2 Biased?

Saki Takahashi  1 , Bryan Greenhouse  1   2 , Isabel Rodríguez-Barraquer  1
Affiliations

Are Seroprevalence Estimates for Severe Acute Respiratory Syndrome Coronavirus 2 Biased?

Saki Takahashi et al. J Infect Dis. .

Abstract

Biased seroprevalence estimates can occur using serological assays optimized with validation sets unrepresentative of disease spectrum in the general population. Correct interpretation of serosurveys for severe acute respiratory syndrome coronavirus 2 requires quantifying variations in sensitivity with disease severity and over time.

Keywords: COVID-19; SARS-CoV-2 seroprevalence; antibody testing; spectrum bias; test performance.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya.
    Etyang AO, Lucinde R, Karanja H, Kalu C, Mugo D, Nyagwange J, Gitonga J, Tuju J, Wanjiku P, Karani A, Mutua S, Maroko H, Nzomo E, Maitha E, Kamuri E, Kaugiria T, Weru J, Ochola LB, Kilimo N, Charo S, Emukule N, Moracha W, Mukabi D, Okuku R, Ogutu M, Angujo B, Otiende M, Bottomley C, Otieno E, Ndwiga L, Nyaguara A, Voller S, Agoti CN, Nokes DJ, Ochola-Oyier LI, Aman R, Amoth P, Mwangangi M, Kasera K, Ng'ang'a W, Adetifa IMO, Wangeci Kagucia E, Gallagher K, Uyoga S, Tsofa B, Barasa E, Bejon P, Scott JAG, Agweyu A, Warimwe GM. Etyang AO, et al. Clin Infect Dis. 2022 Jan 29;74(2):288-293. doi: 10.1093/cid/ciab346. Clin Infect Dis. 2022. PMID: 33893491 Free PMC article.
  • Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.
    Alkharaan H, Bayati S, Hellström C, Aleman S, Olsson A, Lindahl K, Bogdanovic G, Healy K, Tsilingaridis G, De Palma P, Hober S, Månberg A, Nilsson P, Pin E, Sällberg Chen M. Alkharaan H, et al. J Infect Dis. 2021 Aug 2;224(3):407-414. doi: 10.1093/infdis/jiab256. J Infect Dis. 2021. PMID: 33978762 Free PMC article.
  • Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.
    Hober S, Hellström C, Olofsson J, Andersson E, Bergström S, Jernbom Falk A, Bayati S, Mravinacova S, Sjöberg R, Yousef J, Skoglund L, Kanje S, Berling A, Svensson AS, Jensen G, Enstedt H, Afshari D, Xu LL, Zwahlen M, von Feilitzen K, Hanke L, Murrell B, McInerney G, Karlsson Hedestam GB, Lendel C, Roth RG, Skoog I, Svenungsson E, Olsson T, Fogdell-Hahn A, Lindroth Y, Lundgren M, Maleki KT, Lagerqvist N, Klingström J, Da Silva Rodrigues R, Muschiol S, Bogdanovic G, Arroyo Mühr LS, Eklund C, Lagheden C, Dillner J, Sivertsson Å, Havervall S, Thålin C, Tegel H, Pin E, Månberg A, Hedhammar M, Nilsson P. Hober S, et al. Clin Transl Immunology. 2021 Jul 19;10(7):e1312. doi: 10.1002/cti2.1312. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34295471 Free PMC article.
  • Estimating geographic variation of infection fatality ratios during epidemics.
    Ladau J, Brodie EL, Falco N, Bansal I, Hoffman EB, Joachimiak MP, Mora AM, Walker AM, Wainwright HM, Wu Y, Pavicic M, Jacobson D, Hess M, Brown JB, Abuabara K. Ladau J, et al. Infect Dis Model. 2024 Mar 4;9(2):634-643. doi: 10.1016/j.idm.2024.02.009. eCollection 2024 Jun. Infect Dis Model. 2024. PMID: 38572058 Free PMC article.
  • Multiplex assays for the identification of serological signatures of SARS-CoV-2 infection: an antibody-based diagnostic and machine learning study.
    Rosado J, Pelleau S, Cockram C, Merkling SH, Nekkab N, Demeret C, Meola A, Kerneis S, Terrier B, Fafi-Kremer S, de Seze J, Bruel T, Dejardin F, Petres S, Longley R, Fontanet A, Backovic M, Mueller I, White MT. Rosado J, et al. Lancet Microbe. 2021 Feb;2(2):e60-e69. doi: 10.1016/S2666-5247(20)30197-X. Epub 2020 Dec 21. Lancet Microbe. 2021. PMID: 33521709 Free PMC article.
See all "Cited by" articles

Publication types

Substances