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. 2020 Nov 9;222(11):1772-1775.
doi: 10.1093/infdis/jiaa523.

Are Seroprevalence Estimates for Severe Acute Respiratory Syndrome Coronavirus 2 Biased?

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Are Seroprevalence Estimates for Severe Acute Respiratory Syndrome Coronavirus 2 Biased?

Saki Takahashi et al. J Infect Dis. .

Abstract

Biased seroprevalence estimates can occur using serological assays optimized with validation sets unrepresentative of disease spectrum in the general population. Correct interpretation of serosurveys for severe acute respiratory syndrome coronavirus 2 requires quantifying variations in sensitivity with disease severity and over time.

Keywords: COVID-19; SARS-CoV-2 seroprevalence; antibody testing; spectrum bias; test performance.

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