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Review
. 2020 Aug 28;20(10):49.
doi: 10.1007/s11892-020-01333-9.

The Contribution of Kidney Disease to Cognitive Impairment in Patients with Type 2 Diabetes

Shivani Ghoshal  1 , Nicholette D Allred  2 , Barry I Freedman  3
Affiliations
Review

The Contribution of Kidney Disease to Cognitive Impairment in Patients with Type 2 Diabetes

Shivani Ghoshal et al. Curr Diab Rep. .

Abstract

Purpose of review: This review focuses on the relationships between diabetes, cognitive impairment, and the contribution of kidney disease.

Recent findings: We review the independent contributions of parameters of kidney disease, including albuminuria, glomerular filtration, bone/mineral metabolism, and vitamin D synthesis, on cognitive performance in patients with diabetes. Potential pathophysiologic mechanisms underlying these associations are discussed highlighting gaps in existing knowledge. Finally, effects of the dialysis procedure on the brain and cognitive performance are considered. Emphasis is placed on novel non-invasive screening tools with the potential to preserve cerebral perfusion during hemodialysis and limit cognitive decline in patients with diabetic ESKD. Patients with type 2 diabetes and advanced chronic kidney disease suffer a higher prevalence of cognitive impairment. This is particularly true in patients with diabetes and end-stage kidney disease (ESKD).

Keywords: Albuminuria; Brain; Chronic kidney disease; Cognition; Diabetes mellitus; Stroke.

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