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Comparative Study
. 2021 Jan;174(1):131-133.
doi: 10.7326/M20-4738. Epub 2020 Aug 28.

Salivary Detection of COVID-19

Affiliations
Comparative Study

Salivary Detection of COVID-19

Lisa Caulley et al. Ann Intern Med. 2021 Jan.
No abstract available

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Conflict of interest statement

Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-4738.

Figures

Figure.
Figure.. Study flow diagram.
Standard swab and saliva sample collection during the study period. COVID-19 = coronavirus disease 2019. * Inclusion criteria were age ≥18 y, provision of informed consent, and being high-risk asymptomatic or having mild symptoms of COVID-19. Patients were screened before entry by a physician. Those with severe symptoms were redirected to an emergency department for formal clinical evaluation. † Eight participants were tested twice at the testing center (for both standard swab and saliva sample). Two tested positive on their initial oropharyngeal swab and negative on a saliva sample. These participants' results remained positive on an oropharyngeal swab and negative on a saliva sample on repeated testing (5 d and 8 d later). One participant tested positive on the initial oropharyngeal swab and negative on the saliva sample. This participant tested negative on both specimens 7 d later. The remaining 6 participants tested negative on initial and repeated testing for both specimens.

References

    1. Wasserman JK, Rourke R, Purgina B, et al. HPV DNA in saliva from patients with SCC of the head and neck is specific for p16-positive oropharyngeal tumours. J Otolaryngol Head Neck Surg. 2017;46:3. [PMID: 28061890] doi:10.1186/s40463-016-0179-6 - PMC - PubMed
    1. Czumbel LM, Kiss S, Farkas N, et al. Saliva as a candidate for COVID-19 diagnostic testing: a meta-analysis. Front Med (Lausanne). 2020;7:465. doi:10.3389/fmed.2020.00465 - PMC - PubMed
    1. Kucirka LM, Lauer SA, Laeyendecker O, et al. Variation in false-negative rate of reverse transcriptase polymerase chain reaction–based SARS-CoV-2 tests by time since exposure. Ann Intern Med. 2020;173:262-267. [PMID: 32422057] doi:10.7326/M20-1495 - PMC - PubMed
    1. Patel MR, Carroll D, Ussery E, et al. Performance of oropharyngeal swab testing compared to nasopharyngeal swab testing for diagnosis of COVID-19 —United States, January-February 2020. Clin Infect Dis. 2020. [PMID: 32548635] doi:10.1093/cid/ciaa759 - PMC - PubMed
    1. Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25. [PMID: 31992387] doi:10.2807/1560-7917.ES.2020.25.3.2000045 - PMC - PubMed