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. 2021 Aug 2;73(3):545-548.
doi: 10.1093/cid/ciaa1286.

Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial Polymerase Chain Reaction Testing, and Cohorting of Positive Severe Acute Respiratory Syndrome Coronavirus 2 Patients in a Skilled Nursing Facility

Amy V Dora  1 , Alexander Winnett  1 , Jennifer A Fulcher  1   2 , Linda Sohn  3 , Feliza Calub  2 , Ian Lee-Chang  2 , Elham Ghadishah  3 , William A Schwartzman  2 , David O Beenhouwer  2 , John Vallone  4 , Christopher J Graber  2 , Matthew Bidwell Goetz  2 , Debika Bhattacharya  1   2
Affiliations

Using Serologic Testing to Assess the Effectiveness of Outbreak Control Efforts, Serial Polymerase Chain Reaction Testing, and Cohorting of Positive Severe Acute Respiratory Syndrome Coronavirus 2 Patients in a Skilled Nursing Facility

Amy V Dora et al. Clin Infect Dis. .

Abstract

We characterized serology following a nursing home outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where residents were serially tested by reverse-transcription polymerase chain reaction (RT-PCR) and positive residents were cohorted. When tested 46-76 days later, 24 of 26 RT-PCR-positive residents were seropositive; none of the 124 RT-PCR-negative residents had confirmed seropositivity, supporting serial SARS-CoV-2 RT-PCR testing and cohorting in nursing homes.

Keywords: COVID-19; SARS-CoV-2 serology; infection control; long-term care facility.

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