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Comment
. 2020 Sep 14;38(3):317-319.
doi: 10.1016/j.ccell.2020.07.012. Epub 2020 Aug 27.

Breaking Barriers in HER2+ Cancers

Salvatore Siena  1 , Silvia Marsoni  2 , Andrea Sartore-Bianchi  3
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Free article
Comment

Breaking Barriers in HER2+ Cancers

Salvatore Siena et al. Cancer Cell. .
Free article

Abstract

Treatment with the immunoconjugate trastuzumab deruxtecan leads to unprecedented improvements in response and overall survival in patients with HER2-positive (HER2+) metastatic gastroesophageal carcinoma (GEA), according to a study published in the New England Journal of Medicine. Until now, no HER2-targeted drugs other than trastuzumab have shown significant benefit in patients with HER2+ GEA.

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  • Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer.
    Shitara K, Bang YJ, Iwasa S, Sugimoto N, Ryu MH, Sakai D, Chung HC, Kawakami H, Yabusaki H, Lee J, Saito K, Kawaguchi Y, Kamio T, Kojima A, Sugihara M, Yamaguchi K; DESTINY-Gastric01 Investigators. Shitara K, et al. N Engl J Med. 2020 Jun 18;382(25):2419-2430. doi: 10.1056/NEJMoa2004413. Epub 2020 May 29. N Engl J Med. 2020. PMID: 32469182 Clinical Trial.

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