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Case Reports
. 2020 Oct;8(10):1057-1060.
doi: 10.1016/S2213-2600(20)30361-1. Epub 2020 Aug 25.

Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient

Christian Lang  1 , Peter Jaksch  1 , Mir Alireza Hoda  1 , György Lang  1 , Thomas Staudinger  2 , Edda Tschernko  3 , Bernhard Zapletal  3 , Silvana Geleff  4 , Helmut Prosch  5 , Riem Gawish  6 , Sylvia Knapp  6 , Oliver Robak  2 , Florian Thalhammer  7 , Alexander Indra  8 , Markus Koestenberger  9 , Robert Strassl  10 , Thomas Klikovits  1 , Kamran Ali  1 , Gottfried Fischer  11 , Walter Klepetko  1 , Konrad Hoetzenecker  12 , Peter Schellongowski  2
Affiliations
Case Reports

Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient

Christian Lang et al. Lancet Respir Med. 2020 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Radiological imaging and pathological examinations Chest x-rays of the patient on day 6 after the initial SARS-CoV-2-positive PCR result, on admission to the intensive care unit (A); and on day 52, when she was put on the transplantation waiting list (B). Chest x-ray after lung transplantation on day 62 (postoperative day 4; C). CT on day 49 showed air-filled cystic spaces, indicating necrotic lung tissue (D); and missing contrast enhancement in the periphery of the right lower lobe, suggesting thrombosis of small pulmonary vessels (E). Macroscopic appearance of the explanted lungs showed extensive necrosis (F). Microscopic images of haematoxylin and eosin staining of the explanted lungs showed diffuse alveolar damage, inflammatory granulation (original magnification × 40; G) and thrombosis of middle-sized arteries (original magnification × 16; H). SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.
Figure 2
Figure 2
Patient timeline (A) Clinical events. (B) SARS-CoV-2 tests, including PCR and Vero cell culture. Ct=cycle threshold. ECMO=extracorporeal membrane oxygenation. ICU=intensive care unit. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

Comment in

  • When to consider lung transplantation for COVID-19.
    Cypel M, Keshavjee S. Cypel M, et al. Lancet Respir Med. 2020 Oct;8(10):944-946. doi: 10.1016/S2213-2600(20)30393-3. Epub 2020 Aug 25. Lancet Respir Med. 2020. PMID: 32857989 Free PMC article. No abstract available.

References

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    1. Chang Y, Lee SO, Shim TS. Lung transplantation as a therapeutic option in acute respiratory distress syndrome. Transplantation. 2018;102:829–837. - PubMed

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