Olfactory disorder in patients infected with SARS-CoV-2

doi:10.1016/j.jmii.2020.08.010

. 2021 Oct;54(5):992-996.

doi: 10.1016/j.jmii.2020.08.010. Epub 2020 Aug 20.

Olfactory disorder in patients infected with SARS-CoV-2

Affiliations

¹ Section of Infectious Diseases, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan; Institute of Public Health, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. Electronic address: yfyen1@gmail.com.
² Section of Infectious Diseases, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan; School of Medicine, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan.
³ Department of Internal Medicine, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan.
⁴ School of Medicine, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; Department of Internal Medicine, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan.
⁵ Department of Education and Research, Taipei City Hospital, 145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan; Department of Pediatrics, Taipei City Hospital, Zhongxiao Branch, 87, Tongde Rd., Nangang Dist., Taipei City, 11556, Taiwan.
⁶ Department of Family Medicine, Taipei City Hospital, Renai Branch, 4, Renai Rd., Daan Dist., Taipei City, 106, Taiwan.
⁷ Department of Education and Research, Taipei City Hospital, 145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan.
⁸ Department of Dentistry, Taipei City Hospital, No.145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan; Department of Dentistry, School of Dentistry, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; University of Taipei, Taipei, No. 1, Aiguo West Road, Zhongzheng District, Taipei City, 100, Taiwan. Electronic address: DAE30@tpech.gov.tw.
⁹ Institute of Public Health, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, 145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan; Department of Neurosurgery, Taipei City Hospital, No.145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan.

PMID: 32859529
PMCID: PMC7439082
DOI: 10.1016/j.jmii.2020.08.010

Olfactory disorder in patients infected with SARS-CoV-2

Yung-Feng Yen et al. J Microbiol Immunol Infect. 2021 Oct.

. 2021 Oct;54(5):992-996.

doi: 10.1016/j.jmii.2020.08.010. Epub 2020 Aug 20.

Authors

Affiliations

¹ Section of Infectious Diseases, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan; Institute of Public Health, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. Electronic address: yfyen1@gmail.com.
² Section of Infectious Diseases, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan; School of Medicine, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan.
³ Department of Internal Medicine, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan.
⁴ School of Medicine, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; Department of Internal Medicine, Taipei City Hospital, Yangming Branch, 105, Yusheng St., Shilin Dist., Taipei City, 111, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan.
⁵ Department of Education and Research, Taipei City Hospital, 145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan; Department of Pediatrics, Taipei City Hospital, Zhongxiao Branch, 87, Tongde Rd., Nangang Dist., Taipei City, 11556, Taiwan.
⁶ Department of Family Medicine, Taipei City Hospital, Renai Branch, 4, Renai Rd., Daan Dist., Taipei City, 106, Taiwan.
⁷ Department of Education and Research, Taipei City Hospital, 145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan.
⁸ Department of Dentistry, Taipei City Hospital, No.145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan; Department of Dentistry, School of Dentistry, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; University of Taipei, Taipei, No. 1, Aiguo West Road, Zhongzheng District, Taipei City, 100, Taiwan. Electronic address: DAE30@tpech.gov.tw.
⁹ Institute of Public Health, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, 145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan; Department of Neurosurgery, Taipei City Hospital, No.145, Zhengzhou Rd., Datong Dist., Taipei City, 103, Taiwan.

PMID: 32859529
PMCID: PMC7439082
DOI: 10.1016/j.jmii.2020.08.010

Abstract

Three (60%) of five patients with coronavirus disease 2019 (COVID-19) had olfactory disorder. Two exhibited anosmia at the onset of COVID-19, while one had hyposmia 4 days after the onset of COVID-19. All patients with olfactory disorder were completely recovered with a mean recovery length of 11.3 days.

Keywords: COVID-19; Olfactory disorder; SARS-CoV-2.

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Conflict of interest statement

Declaration of Competing Interest No conflict of interest exists for the author.

Figures

**Figure 1**
Time course of olfactory disorder and RT-PCR assay in COVID-19 patients. Abbreviations: SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; RT-PCR, real-time reverse transcriptase–polymerase chain reaction; COVID-19, coronavirus disease 2019.

See this image and copyright information in PMC

Cited by

Management of Anosmia in COVID-19: A Comprehensive Review.
Khurana K, Singh CV. Khurana K, et al. Cureus. 2022 Oct 18;14(10):e30425. doi: 10.7759/cureus.30425. eCollection 2022 Oct. Cureus. 2022. PMID: 36407192 Free PMC article. Review.

References

1. World Health Organization Coronavirus disease (COVID-19) pandemic. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/
1. Taiwan Centers for Disease Control and Prevention Surveillance of COVID-19. https://www.cdc.gov.tw/En
1. Zou X., Chen K., Zou J., Han P., Hao J., Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020 Apr;14(2):185–192. - PMC - PubMed
1. Fu Y., Cheng Y., Wu Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol Sin. 2020 Jun;35(3):266–271. - PMC - PubMed
1. Eliezer M., Hautefort C., Hamel A.L., Verillaud B., Herman P., Houdart E. Sudden and complete olfactory loss function as a possible symptom of COVID-19. JAMA Otolaryngol Head Neck Surg. 2020 - PubMed

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[1] World Health Organization Coronavirus disease (COVID-19) pandemic. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/

[2] World Health Organization Coronavirus disease (COVID-19) pandemic. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/

[3] Taiwan Centers for Disease Control and Prevention Surveillance of COVID-19. https://www.cdc.gov.tw/En

[4] Taiwan Centers for Disease Control and Prevention Surveillance of COVID-19. https://www.cdc.gov.tw/En

[5] Zou X., Chen K., Zou J., Han P., Hao J., Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020 Apr;14(2):185–192. - PMC - PubMed

[6] Zou X., Chen K., Zou J., Han P., Hao J., Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020 Apr;14(2):185–192. - PMC - PubMed

[7] Fu Y., Cheng Y., Wu Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol Sin. 2020 Jun;35(3):266–271. - PMC - PubMed

[8] Fu Y., Cheng Y., Wu Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol Sin. 2020 Jun;35(3):266–271. - PMC - PubMed

[9] Eliezer M., Hautefort C., Hamel A.L., Verillaud B., Herman P., Houdart E. Sudden and complete olfactory loss function as a possible symptom of COVID-19. JAMA Otolaryngol Head Neck Surg. 2020 - PubMed

[10] Eliezer M., Hautefort C., Hamel A.L., Verillaud B., Herman P., Houdart E. Sudden and complete olfactory loss function as a possible symptom of COVID-19. JAMA Otolaryngol Head Neck Surg. 2020 - PubMed

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Olfactory disorder in patients infected with SARS-CoV-2

Affiliations

Olfactory disorder in patients infected with SARS-CoV-2

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Conflict of interest statement

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