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. 2020 Dec;9(4):807-821.
doi: 10.1007/s40121-020-00331-4. Epub 2020 Aug 28.

Genetic Risk Surveillance for Invasive Aspergillosis in Hematology Patients: A Prospective Observational Study

Tananun Tanpaibule  1 , Natini Jinawath  2   3 , Aruchalean Taweewongsounton  4 , Pimjai Niparuck  5 , Porpon Rotjanapan  6
Affiliations

Genetic Risk Surveillance for Invasive Aspergillosis in Hematology Patients: A Prospective Observational Study

Tananun Tanpaibule et al. Infect Dis Ther. 2020 Dec.

Abstract

Introduction: The association between genetic background and the risk of invasive aspergillosis (IA) has not been addressed in Thailand. We conducted genetic risk surveillance for IA among Thai hematologic patients.

Methods: We conducted a prospective observational cohort study including moderate- to high-risk hematology patients at Ramathibodi Hospital. IA occurrence, relevant clinical data, and genetic analyses were assessed. Odds ratios (ORs) of IA were assessed for the presence of the selected single nucleotide polymorphism genotype using logistic regression.

Results: A total of 357 patients were enrolled. The most common hematologic disease was non-Hodgkin lymphoma (45.1%). IA was diagnosed in 36 patients (10.10%). The C allele of IL10rs1800896 was associated with an increased risk of IA (adjusted OR 5.297; 95% confidence interval [CI] 2.032-13.809, p = 0.001). In multivariate Cox regression analysis, prolonged neutropenia and the C allele of IL10rs1800896 were associated with IA (hazard ratio [HR] 12.585; 95% CI 3.866-40.967, p < 0.001 and HR 2.449; 95% CI 1.097-5.468, p = 0.042, respectively).

Conclusions: Carrying the C allele of IL10rs1800896 was associated with an increased risk of IA among moderate- to high-risk Thai patients with hematologic diseases. This finding can potentially lead to a novel risk stratification scheme to further prevent IA in resource-limited settings.

Keywords: Antifungal prophylaxis; Genetic susceptibility; Hematology patients; Invasive aspergillosis.

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Figures

Fig. 1
Fig. 1
Kaplan–Meier analysis shows association of IL10rs1800896 genotype and cumulative risk of IA
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References

    1. Kosmidis C, Denning DW. The clinical spectrum of pulmonary aspergillosis. Thorax. 2015;70:270–277. - PubMed
    1. Kontoyiannis DP, Marr KA, Park BJ, et al. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis. 2010;50:1091–1100. - PubMed
    1. Pagano L, Caira M, Candoni A, et al. Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study. Haematologica. 2010;95:644–650. - PMC - PubMed
    1. Pagano L, Caira M, Candoni A, et al. The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica. 2006;91:1068–1075. - PubMed
    1. Girmenia C, Ferretti A, Barberi W. Epidemiology and risk factors for invasive fungal diseases in hematopoietic stem cell transplantation. Curr Opin Hematol. 2014;21:459–465. - PubMed

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