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Review
. 2021 Mar;39(3):473-484.
doi: 10.1002/jor.24842. Epub 2020 Sep 22.

Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics

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Free article
Review

Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics

Taylor B Lawson et al. J Orthop Res. 2021 Mar.
Free article

Abstract

Osteoarthritis (OA) is a multifactorial disease of the entire joint which afflicts 140 million individuals worldwide regardless of economic or social status. Current clinical treatments for OA primarily center on reducing pain and increasing mobility, and there are limited therapeutic interventions to restore degraded cartilage or slow disease pathogenesis. This second installment of a two-part review on nanotechnology and OA focuses on novel treatment strategies. Specifically, Part 2 first discusses current surgical and nonsurgical treatments for OA and then summarizes recent advancements in nanotechnology-based treatments, while Part 1 (10.1002/jor.24817) described advances in imaging and diagnostics. We review nano delivery systems for small molecule drugs, nucleic acids, and proteins followed by nano-based scaffolds for neocartilage formation and osteochondral regeneration, and lastly nanoparticle lubricants. We conclude by identifying opportunities for nanomedicine advances, and prospects for OA treatments.

Keywords: biomechanics; osteoarthritis; repair; tissue engineering; treatment.

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References

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