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Comment
. 2020 Nov-Dec;49(6):887-889.
doi: 10.1016/j.hrtlng.2020.07.012. Epub 2020 Aug 11.

Statins in COVID-19: A new ray of hope

Shekhar Kunal  1 , Kashish Gupta  2 , Sanjay Gupta  3
Affiliations
Comment

Statins in COVID-19: A new ray of hope

Shekhar Kunal et al. Heart Lung. 2020 Nov-Dec.
No abstract available

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Conflict of interest statement

Declaration of Competing Interests Authors have no conflict of interest to disclose

Figures

Fig 1
Fig. 1
Pictographic representation showing the potential role of statins in COVID-19 infection. SARS-CoV-2 activates the immune response through interaction with various inflammatory cells followed by release of inflammatory cytokines and host cell damage through the MYD88-NF-κB pathway culminating in ARDS, myocarditis and shock. In addition, SARS-CoV-2 also leads to a pro-coagulant state through activation of tissue-factor pathway and by virtue of a pro-inflammatory state. Statins have a pleotropic response and has anti-inflammatory action through (i) reduced MHC-class II expression on APCs hence decreased T-cell stimulation, (ii) reduced T-cell activation and (iii) downregulation of MYD88-NF-κB pathway. In addition, statins also exert an anti-coagulant and vasodilatory effects thus mitigating the adverse effects of “cytokine storm” in COVID-19. APCs: Antigen Presenting Cells; ARDS: Acute Respiratory Distress Syndrome; MHC: Major Histocompatibility Complex. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

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