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Review
. 2020 Nov:88:106928.
doi: 10.1016/j.intimp.2020.106928. Epub 2020 Aug 24.

Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine

Rasoul Mirzaei  1 , Rokhsareh Mohammadzadeh  2 , Farzad Mahdavi  3 , Fariba Badrzadeh  4 , Sheida Kazemi  5 , Mehdi Ebrahimi  6 , Fatemeh Soltani  7 , Sima Kazemi  8 , Ali Salimi Jeda  9 , Mohammad Darvishmotevalli  10 , Rasoul Yousefimashouf  8 , Hossein Keyvani  11 , Sajad Karampoor  12
Affiliations
Review

Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine

Rasoul Mirzaei et al. Int Immunopharmacol. 2020 Nov.

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Nevertheless, currently, no proven effective therapies for this virus exists. The vaccines are deemed as a significant part of disease prevention for emerging viral diseases, since, in several cases, other therapeutic choices are limited or non-existent, or that diseases result in such an accelerated clinical worsening that the efficacy of treatments is restricted. Therefore, effective vaccines against COVID-19 are urgently required to overcome the tremendous burden of mortality and morbidity correlated with SARS-CoV-2. In this review, we will describe the latest evidence regarding outstanding vaccine approaches and the challenges for vaccine production.

Keywords: COVID-19; Immunopathogenesis; SARS-CoV-2; Vaccines.

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Conflict of interest statement

Declaration of Competing Interest Nothing declared.

Figures

Fig. 1
Fig. 1
The SARS-CoV-2 immunopathogenesis in the lung.
Fig. 2
Fig. 2
The current approaches considered for SARS-CoV-2.
Fig. 3
Fig. 3
The current ongoing clinical trial for candidate SARS-CoV-2 vaccines.
See this image and copyright information in PMC

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