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. 2020 May 13;16(5):985-992.
doi: 10.5114/aoms.2020.95336. eCollection 2020.

Particulate matter pollution and the COVID-19 outbreak: results from Italian regions and provinces

Vanessa Bianconi  1 , Paola Bronzo  1 , Maciej Banach  2   3 , Amirhossein Sahebkar  4   5 , Massimo R Mannarino  1 , Matteo Pirro  1
Affiliations

Particulate matter pollution and the COVID-19 outbreak: results from Italian regions and provinces

Vanessa Bianconi et al. Arch Med Sci. .

Abstract

Introduction: Particulate matter exposure has been associated with the appearance and severity of several diseases, including viral infections. The aim of this study was to investigate whether coronavirus disease 2019 (COVID-19) cases and deaths across Italian regions and provinces in March 2020 were linked to past exposure to fine and coarse particulate matter (namely, PM2.5 and PM10, respectively).

Material and methods: Geographical distributions of COVID-19 cases and deaths (105,792 and 12,428, respectively, up to 31st March 2020), PM2.5 and PM10 exposure, and demographic characteristics were extracted from publicly accessible databases. Adjusted regression models were performed to test the association between particulate matter exposure in different Italian regions and provinces and COVID-19 incidence proportions and death rates.

Results: A heterogeneous distribution of COVID-19 cases/deaths and particulate matter exposure was observed in Italy, with the highest numbers in Northern Italy regions and provinces. Independent associations between regional PM2.5/PM10 exposure and COVID-19 incidence proportion and death rate were observed (COVID-19 incidence proportion: β = 0.71, p = 0.003, β = 0.61, p = 0.031, respectively; COVID-19 death rate: β = 0.68, p = 0.004 and β = 0.61, p = 0.029, respectively). Similarly, PM2.5/PM10 exposures were independently associated with COVID-19 incidence proportion (β = 0.26, p = 0.024 and β = 0.27, p = 0.006, respectively) at the provincial level. The number of days exceeding the provincial limit value of exposure to PM10 (50 µg/m3) was also independently associated with the COVID-19 incidence proportion (β = 0.30, p = 0.008).

Conclusions: Exposure to PM2.5 and PM10 is associated with COVID-19 cases and deaths, suggesting that particulate matter pollution may play a role in the COVID-19 outbreak and explain the heterogeneous distribution of COVID-19 in Italian regions and provinces.

Keywords: PM10; PM2.5; SARS-CoV-2; deaths; incidence.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Total number of COVID-19 cases and deaths in Italy from 1st March to 31st March, 2020
Figure 2
Figure 2
Mean exposure to particulate matter (PM2.5 and PM10) in Italian regions (A) and provinces stratified according to geographical positioning (i.e. North, Centre, South-Islands) (B). ISPRA PM exposure data were not available for Basilicata and Molise regions, whereas public availability was limited to PM10 data for 6 provinces in the Sicilia region. *P < 0.001 for PM10 comparisons with Northern provinces, # p < 0.001 for PM2.5 comparisons with Northern provinces
Figure 3
Figure 3
Number of days exceeding the recommended PM10 limits (> 50 μg/m3) in Italian provinces according to ISPRA (2017)
Figure 4
Figure 4
Correlation between the number of COVID-19 cases in Italian provinces and either PM2.5 (A) or PM10 (B) exposure
See this image and copyright information in PMC

References

    1. Coronavirus disease 2019 (COVID-19) Situation Report – 79. http://www.who.int. Accessed on May 9th 2020.
    1. Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m10918. - PMC - PubMed
    1. Borgio J, Alsuwat H, Al Otaibi W, et al. State-of-the-art tools unveil potent drug targets amongst clinically approved drugs to inhibit helicase in SARS-CoV-2. Arch Med Sci. 2020;16:508–18. - PMC - PubMed
    1. Reiner Ž, Hatamipour M, Banach M, et al. Statins and the COVID-19 main protease: in silico evidence on direct interaction. Arch Med Sci. 2020;16:490–6. - PMC - PubMed
    1. Kim KH, Kabir E, Kabir S. A review on the human health impact of airborne particulate matter. Environ Int. 2015;74:136–3. - PubMed