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Comment
. 2020 Aug 25;1(5):100079.
doi: 10.1016/j.xcrm.2020.100079.

Black Lives Matter Worldwide: Retooling Precision Oncology for True Equity of Cancer Care

Padma Sheila Rajagopal  1 , Olufunmilayo I Olopade  1   2
Affiliations
Comment

Black Lives Matter Worldwide: Retooling Precision Oncology for True Equity of Cancer Care

Padma Sheila Rajagopal et al. Cell Rep Med. .

Abstract

In a recent issue of Cancer Cell, Carrot-Zhang et al. identified ancestry-specific molecular variants and expression changes among patients from The Cancer Genome Atlas (TCGA).1 Their study findings and limitations highlight the critical need to diversify populations represented in cancer genomics research.

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Comment on

  • Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.
    Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E; Cancer Genome Atlas Analysis Network; Cherniack AD, Beroukhim R. Carrot-Zhang J, et al. Cancer Cell. 2020 May 11;37(5):639-654.e6. doi: 10.1016/j.ccell.2020.04.012. Cancer Cell. 2020. PMID: 32396860 Free PMC article.

References

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    1. Yuan J., Hu Z., Mahal B.A., Zhao S.D., Kensler K.H., Pi J., Hu X., Zhang Y., Wang Y., Jiang J. Integrated analysis of genetic ancestry and genomic alterations across cancers. Cancer Cell. 2018;34:549–560.e9. - PMC - PubMed
    1. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium Pan-cancer analysis of whole genomes. Nature. 2020;578:82–93. - PMC - PubMed
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    1. Huo D., Hu H., Rhie S.K., Gamazon E.R., Cherniack A.D., Liu J., Yoshimatsu T.F., Pitt J.J., Hoadley K.A., Troester M. Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas. JAMA Oncol. 2017;3:1654–1662. - PMC - PubMed

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