Colchicine Attenuates Inflammation Beyond the Inflammasome in Chronic Coronary Artery Disease: A LoDoCo2 Proteomic Substudy

Tjerk S J Opstal^{1

2}, Renate M Hoogeveen^#³, Aernoud T L Fiolet^#^{4

5}, Max J M Silvis⁴, Salem H K The⁶, Willem A Bax⁷, Dominique P V de Kleijn^{4

8

9}, Arend Mosterd^{10

5

11}, Erik S G Stroes³, Jan H Cornel^{1

2

5}

Affiliations

¹ Department of Cardiology, Northwest Clinics, Alkmaar, the Netherlands (T.S.J.O., J.H.C.).
² Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands (T.S.J.O., J.H.C.).
³ Department of Vascular Medicine, Amsterdam University Medical Centers, the Netherlands (R.M.H., E.S.G.S.).
⁴ Departments of Cardiology (A.T.L.F., M.J.M.S., D.P.V.d.K.), University Medical Center Utrecht, the Netherlands.
⁵ Dutch Network for Cardiovascular Research, Utrecht, the Netherlands (A.T.L.F., A.M., J.H.C.).
⁶ Department of Cardiology, Treant Medical Center, Emmen, the Netherlands (S.H.K.T.).
⁷ Department of Internal Medicine, Northwest Clinics, Alkmaar, the Netherlands (W.A.B.).
⁸ Vascular Surgery (D.P.V.d.K.), University Medical Center Utrecht, the Netherlands.
⁹ Netherlands Heart Institute, Utrecht, the Netherlands (D.P.V.d.K.).
¹⁰ Julius Center for Health Sciences and Primary Care (A.M.), University Medical Center Utrecht, the Netherlands.
¹¹ Department of Cardiology, Meander Medical Center, Amersfoort, the Netherlands (A.M.).

^# Contributed equally.

Clinical Trial

Tjerk S J Opstal et al. Circulation. 2020.

. 2020 Nov 17;142(20):1996-1998.

doi: 10.1161/CIRCULATIONAHA.120.050560. Epub 2020 Aug 31.

¹ Department of Cardiology, Northwest Clinics, Alkmaar, the Netherlands (T.S.J.O., J.H.C.).
² Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands (T.S.J.O., J.H.C.).
³ Department of Vascular Medicine, Amsterdam University Medical Centers, the Netherlands (R.M.H., E.S.G.S.).
⁴ Departments of Cardiology (A.T.L.F., M.J.M.S., D.P.V.d.K.), University Medical Center Utrecht, the Netherlands.
⁵ Dutch Network for Cardiovascular Research, Utrecht, the Netherlands (A.T.L.F., A.M., J.H.C.).
⁶ Department of Cardiology, Treant Medical Center, Emmen, the Netherlands (S.H.K.T.).
⁷ Department of Internal Medicine, Northwest Clinics, Alkmaar, the Netherlands (W.A.B.).
⁸ Vascular Surgery (D.P.V.d.K.), University Medical Center Utrecht, the Netherlands.
⁹ Netherlands Heart Institute, Utrecht, the Netherlands (D.P.V.d.K.).
¹⁰ Julius Center for Health Sciences and Primary Care (A.M.), University Medical Center Utrecht, the Netherlands.
¹¹ Department of Cardiology, Meander Medical Center, Amersfoort, the Netherlands (A.M.).

^# Contributed equally.

No abstract available

Keywords: atherosclerosis; colchicine; coronary artery disease; inflammasomes; inflammation.

Comment in

Colchicine for Secondary Cardiovascular Prevention in Coronary Disease.
Roubille F, Tardif JC. Roubille F, et al. Circulation. 2020 Nov 17;142(20):1901-1904. doi: 10.1161/CIRCULATIONAHA.120.051240. Epub 2020 Nov 16. Circulation. 2020. PMID: 33196312 No abstract available.