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Clinical Trial
. 1988 Mar-Apr;16(2):98-104.
doi: 10.1007/BF01644312.

Ciprofloxacin and norfloxacin for selective decontamination in patients with severe granulocytopenia

G Maschmeyer  1 , E Haralambie, W Gaus, W Kern, A W Dekker, H G De Vries-Hospers, W Sizoo, W König, F Gutzler, S Daenen
Affiliations
Clinical Trial

Ciprofloxacin and norfloxacin for selective decontamination in patients with severe granulocytopenia

G Maschmeyer et al. Infection. 1988 Mar-Apr.

Abstract

In a randomized multicenter study, ciprofloxacin and norfloxacin, each in two different dose regimens and in combination with non-absorbable antimycotics, were administered to 51 patients with acute leukaemia undergoing aggressive remission induction chemotherapy for infection prevention. Both drugs showed an effective elimination of gram-negative potential pathogens and Staphylococcus aureus not affecting the anaerobic flora of the gastrointestinal tract. A low incidence of side effects and a satisfactory patient compliance could be observed. A daily dosage of 1,000 mg ciprofloxacin or 800 mg norfloxacin is recommended for infection prevention in severely granulocytopenic patients.

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