Clinical Trial
doi: 10.1007/BF01644312.
Ciprofloxacin and norfloxacin for selective decontamination in patients with severe granulocytopenia
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- PMID: 3286509
- DOI: 10.1007/BF01644312
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Clinical Trial
Ciprofloxacin and norfloxacin for selective decontamination in patients with severe granulocytopenia
Infection.
1988 Mar-Apr.
Abstract
In a randomized multicenter study, ciprofloxacin and norfloxacin, each in two different dose regimens and in combination with non-absorbable antimycotics, were administered to 51 patients with acute leukaemia undergoing aggressive remission induction chemotherapy for infection prevention. Both drugs showed an effective elimination of gram-negative potential pathogens and Staphylococcus aureus not affecting the anaerobic flora of the gastrointestinal tract. A low incidence of side effects and a satisfactory patient compliance could be observed. A daily dosage of 1,000 mg ciprofloxacin or 800 mg norfloxacin is recommended for infection prevention in severely granulocytopenic patients.
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