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Practice Guideline
. 2021 Jan;99(1):59-67.
doi: 10.1016/j.kint.2020.07.045. Epub 2020 Aug 29.

Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement

Christopher Esezobor  1 , Adebowale D Ademola  2 , Adewale E Adetunji  3 , Emmanuel A Anigilaje  4 , Anthony Batte  5 , Fatima N Jiya-Bello  6 , Francis F Furia  7 , Uzoamaka Muoneke  8 , Mignon McCulloch  9 , Peter Nourse  10 , Patience Obiagwu  11 , Odutola Odetunde  12 , Perditer Okyere  13 , Adaobi Solarin  14 , Elliot K Tannor  15 , Damien Noone  16 , Rasheed Gbadegesin  17 , Rulan S Parekh  18 ; Human Hereditary and Health in Africa Kidney Disease Research Network
Collaborators, Affiliations
Practice Guideline

Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement

Christopher Esezobor et al. Kidney Int. 2021 Jan.
No abstract available

Keywords: Africa; focal segmental glomerulosclerosis (FSGS); idiopathic nephrotic syndrome; minimal change; nephrotic syndrome; steroid resistant; steroid sensitive; sub-Saharan.

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Figures

Figure 1|
Figure 1|. Bubble plots show the responses from the survey based on the type of therapy used in nephrotic syndrome by the duration of use, and the size of the bubble represents the number of responses.
(a) Initial prednisone treatment for steroid-sensitive nephrotic syndrome; (b-d) treatment with steroid-sparing medications.
Figure 2|
Figure 2|. (a) Steroid-sparing agents in order of most commonly used to least commonly used are cyclophosphamide, levamisole, calcineurin inhibitors, MMF, and chlorambucil.
Cyclophosphamide is used in the majority of centers. Chlorambucil is not available in Uganda, Tanzania, Ghana, or Cameroon, it is used primarily in South Africa and in a few clinical sites in Nigeria. Levamisole is not available in Ghana or Cameroon, and is used more routinely in Nigeria, Tanzania, and Uganda. Cyclosporine is the most commonly used calcineurin inhibitor (CNI). MMF is available only in Uganda, Tanzania, Nigeria, and South Africa. (b) African nephrologists used varying definitions for steroid resistance, ranging from 4 to 52 weeks of nonresponse to prednisone, with a median of 8 weeks. IQR, interquartile range.
See this image and copyright information in PMC

References

    1. Banh TH, Hussain-Shamsy N, Patel V, et al. Ethnic differences in incidence and outcomes of childhood nephrotic syndrome. Clin J Am Soc Nephrol. 2016;11:1760–1768. - PMC - PubMed
    1. Esezobor CI, Ladapo TA, Osinaike B, et al. Paediatric acute kidney injury in a tertiary hospital in Nigeria: prevalence, causes and mortality rate. PLoS One. 2012;7:e51229. - PMC - PubMed
    1. Asinobi AO, Ademola AD, Ogunkunle OO, et al. Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria. BMC Nephrol. 2014;15:25. - PMC - PubMed
    1. Abdelraheem MB, Ali el TM, Mohamed RM, et al. Pattern of glomerular diseases in Sudanese children: a clinico-pathological study. Saudi J Kidney Dis Transpl. 2010;21:778–783. - PubMed
    1. Olowu WA, Ademola A, Ajite AB, et al. Childhood nephrotic syndrome in tropical Africa: then and now. Paediatr Int Child Health. 2017;37: 259–268. - PubMed

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