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Comment
. 2020 Dec:196:135-137.
doi: 10.1016/j.thromres.2020.08.026. Epub 2020 Aug 22.

Extensive pulmonary perfusion defects compatible with microthrombosis and thromboembolic disease in severe Covid-19 pneumonia

L F M Beenen  1 , L D Bos  2 , M J Scheerder  3 , N H J Lobé  3 , M C A Muller  4 , M J Schultz  5 , J G van den Aardweg  6 , A Goorhuis  7 , P I Bonta  6 , S Middeldorp  8 , A P Vlaar  4
Affiliations
Comment

Extensive pulmonary perfusion defects compatible with microthrombosis and thromboembolic disease in severe Covid-19 pneumonia

L F M Beenen et al. Thromb Res. 2020 Dec.
No abstract available

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Conflict of interest statement

No conflicts of interest relevant to the work submitted.

Figures

Fig. 1
Fig. 1
Relationship between parenchymal involvement, perfusion defect, pulmonary blood volume for intubated ICU patients (red) and ward patients (blue). Y-axis: Parenchymal involvement with maximal score 20. Left panel, x-axis: perfusion defect as percentage of lung volume. Right panel, x-axis: pulmonary perfused blood volume (PBV) in mL. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Supplement Fig. 1
Supplement Fig. 1
CT and Dual energy CTPA Pulmonary Blood Volume maps in two COVID-19 patients. Top panels: ICU patient with mechanical ventilation. Bottom panels: ward patient. Left panels: CT images in lung setting. Right panels: Perfusion reconstructions. (a) example of extensive involvement of the lung parenchyma (b) pulmonary embolus in the right lower lobe, with bilateral large areas of perfusion defects, also without associated pulmonary emboli. Note the limited areas of normal perfusion (orange) even in visually rather normal appearing lung zones. (c) bilateral posterior consolidations and areas of ground glass. (d) CTPA showed no pulmonary embolism. Homogeneous perfused blood volume in both lungs, with restriction only in the consolidated areas.
Supplement Fig. 2
Supplement Fig. 2
Perfusion defect as percentage of lung volume stratified for the presence of pulmonary embolism for intubated ICU patients (red) and ward patients (blue).
See this image and copyright information in PMC

Comment on

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