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. 2021 Feb;143(2):121-130.
doi: 10.1111/ane.13338. Epub 2020 Sep 20.

Severe neurological nicotine intoxication by e-cigarette liquids: Systematic literature review

Maenia Scarpino  1   2 , Tiziana Rosso  3 , Giovanni Lanzo  1 , Francesco Lolli  4 , Manuela Bonizzoli  5 , Chiara Lazzeri  5 , Guido Mannaioni  6 , Roberto Baronti  7 , Francesco Fattapposta  8 , Antonello Grippo  1   2
Affiliations

Severe neurological nicotine intoxication by e-cigarette liquids: Systematic literature review

Maenia Scarpino et al. Acta Neurol Scand. 2021 Feb.

Abstract

Electronic cigarettes are a popular, easily purchased, alternative source of nicotine that is considered safer than conventional tobacco. However, Intentional or accidental exposure to e-liquid substances, mainly nicotine, can lead to serious, potentially fatal toxicity. Emergency and critical care physicians should keep in mind acute intoxication of this poison with a biphasic toxic syndrome. We highlight its potentially fatal outcome and suggest monitoring the adverse effects of nicotine according to a multimodal protocol integrating somatosensory evoked potentials, electroencephalography and neuroimaging data with anamnestic report and toxicological and laboratory data.

Keywords: brain death; cardiac arrest; e-cigarettes; e-liquid; hypoxic-ischaemic encephalopathy; intoxication; neurological prognostication; nicotine.

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References

REFERENCES

    1. Thornton SL, Oller L, Sawyer T. Fatal intravenous injection of electronic nicotine delivery system refilling solution. J Med Toxicol. 2014;10:202-204.
    1. Maddu N. What is e-Cigarette and Associated Health Risks From the Edited Volume Smoking - Prevention, Cessation and Health Effects Edited by Li Ping Wong and Victor Hoe, 2019, By Narendra Maddu. doi: 10.5772/intechopen.84747 ISBN: 978-1-78923-880-8.
    1. Sommerfeld K, Łukasik-GłeRbocka M, Kulza M, et al. Intravenous and oral suicidal e-liquid poisonings with confirmed nicotine and cotinine concentrations. For Sci Int. 2016;262:15-20.
    1. Solarino B, Rosenbaum F, Riesselmann B, et al. Death due to ingestion of nicotine-containing solution: case report and review of the literature. Forensic Sci Int. 2010;195:e19-e22.
    1. Lardi C, Vogt S, Pollak S, Thierauf A. Complex suicide with homemade nicotine patches. Forensic Sci Int. 2014;236:14-18.

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