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Review
. 2020 Aug 27;10(9):165.
doi: 10.3390/life10090165.

Cardiovascular System in COVID-19: Simply a Viewer or a Leading Actor?

Filiberto Fausto Mottola  1 , Nicoletta Verde  1 , Riccardo Ricciolino  1 , Marco Di Di Mauro  1 , Marco Giuseppe Migliaccio  1 , Vincenzo Carfora  1 , Giorgio Spiniello  1 , Nicola Coppola  2 , Vanvitelli Covid-Group
Affiliations
Review

Cardiovascular System in COVID-19: Simply a Viewer or a Leading Actor?

Filiberto Fausto Mottola et al. Life (Basel). .

Abstract

As of January 2020, a new pandemic has spread from Wuhan and caused thousands of deaths worldwide. Several studies have observed a relationship between coronavirus disease (COVID-19) infection and the cardiovascular system with the appearance of myocardial damage, myocarditis, pericarditis, heart failure and various arrhythmic manifestations, as well as an increase in thromboembolic risk. Cardiovascular manifestations have been highlighted especially in older and more fragile patients and in those with multiple cardiovascular risk factors such as cancer, diabetes, obesity and hypertension. In this review, we will examine the cardiac involvement associated with SARS-CoV-2 infection, focusing on the pathophysiological mechanism underlying manifestations and their clinical implication, taking into account the main scientific papers published to date.

Keywords: SARS-CoV-2 infection; cardiovascular system; heart failure; myocardial injury.

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Conflict of interest statement

The manuscript has been read and approved by all authors and has not been submitted for publication to other journals. We also declare that we have no conflict of interest in connection with this paper.

Figures

Figure 1
Figure 1
SARS-CoV-2 and cardiovascular involvement.
Figure 2
Figure 2
SARS-CoV-2 and management. Heart Failure (HF).
Figure 3
Figure 3
SARS-CoV-2 and ACS management. Type 2 myocardial infarction (type II IM); non-ST segment elevation myocardial infarction (NSTEMI); unstable angina (UA); ST elevation myocardial infarction (STEMI); percutaneous coronary intervention (PCI); dual antiplatelet therapy (DAPT); personal protective equipment (PPE).
Figure 4
Figure 4
Arrhythmic risk management.
See this image and copyright information in PMC

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