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. 2020 Aug 27;9(9):2778.
doi: 10.3390/jcm9092778.

Clinical Application of Forced Oscillation Technique (FOT) in Early Detection of Airway Changes in Smokers

Prem Bhattarai  1 , Stephen Myers  1 , Collin Chia  1   2 , Heinrich C Weber  1   3 , Sally Young  1   4 , Andrew D Williams  1 , Sukhwinder Singh Sohal  1
Affiliations

Clinical Application of Forced Oscillation Technique (FOT) in Early Detection of Airway Changes in Smokers

Prem Bhattarai et al. J Clin Med. .

Abstract

The forced oscillation technique (FOT) is a non-invasive method to assess airway function by emitting oscillatory signals into the respiratory tract during tidal ventilation. This opinion piece discusses the current use, trialled modification and future directions in utilizing FOT as a novel diagnostic tool for early detection of small airway changes in smokers. The published evidence to date has shown that FOT parameters could be a sensitive diagnostic tool to detect early respiratory changes in smokers. Multiple frequencies and the frequency dependence of resistance and reactance can provide the most valuable and early information regarding smoking induced changes in airways. Considering its non-invasiveness, lower level of discomfort to patients than spirometry, feasibility, and cost effectiveness, it could be the first-choice diagnostic technique for detection of early respiratory changes in smokers. The finding of FOT could further be supported and correlated with inflammatory markers.

Keywords: COPD; forced oscillation technique; small airways; smoking.

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Conflict of interest statement

The authors declare no conflict of interest

Figures

Figure 1
Figure 1
Schematic representation of input signal and output response by respiratory system in forced oscillation technique (FOT).
See this image and copyright information in PMC

References

    1. Reitsma M.B., Fullman N., Ng M., Salama J.S., Abajobir A.A., Abate K.H., Abbafati C., Abera S.F., Abraham B., Abyu G.Y., et al. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: A systematic analysis from the Global Burden of Disease Study 2015. Lancet. 2017;389:1885–1906. doi: 10.1016/S0140-6736(17)30819-X. - DOI - PMC - PubMed
    1. Raherison C., Girodet P.-O. Epidemiology of COPD. Eur. Respir. Rev. 2009;18:213–221. doi: 10.1183/09059180.00003609. - DOI - PubMed
    1. Bohadana A.B., Teculescu D., Martinet Y. Mechanisms of chronic airway obstruction in smokers. Respir. Med. 2004;98:139–151. doi: 10.1016/j.rmed.2003.09.005. - DOI - PubMed
    1. Sana A., Somda S.M.A., Meda N., Bouland C. Chronic obstructive pulmonary disease associated with biomass fuel use in women: A systematic review and meta-analysis. BMJ Open Respir. Res. 2018;5:e000246. doi: 10.1136/bmjresp-2017-000246. - DOI - PMC - PubMed
    1. Ramírez-Venegas A., Torres-Duque C.A., Guzmán-Bouilloud N.E., González-García M., Sansores R.H. Small airway disease in COPD associated to biomass exposure. Rev. Investig. Clín. 2019;71:70–78. doi: 10.24875/RIC.18002652. - DOI - PubMed

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