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. 2022 Jul 1;34(3):282-287.
doi: 10.1097/ANA.0000000000000723. Epub 2020 Aug 28.

Brain and Heart Crosstalk During Neurointerventional Procedures: The Role of the Trigeminocardiac Reflex: An Updated Systematic Review

Tumul Chowdhury  1 , Abanoub A Rizk  2 , Emad Al Azazi  1 , Lashmi Venkatraghavan  1 , Jai S Shankar  3 , Bernhard Schaller  4
Affiliations

Brain and Heart Crosstalk During Neurointerventional Procedures: The Role of the Trigeminocardiac Reflex: An Updated Systematic Review

Tumul Chowdhury et al. J Neurosurg Anesthesiol. .

Abstract

The trigeminocardiac reflex is a well-described brainstem reflex that clinically manifests as bradycardia, hypotension, or apnea. This physiological phenomenon is extensively reported during open neurosurgical procedures, but very few data exist for trigeminocardiac reflex occurrence during neurointerventional procedures. This systematic review aims to provide aggregated information related to the trigeminocardiac reflex during neurointerventional procedures and to improve understanding of the various mechanisms that can incite this unique brain-heart crosstalk.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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References

    1. Silvani A, Calandra-Buonaura G, Dampney RA, et al. Brain-heart interactions: physiology and clinical implications. Philos Trans A Math Phys Eng Sci. 2016;374:20150181.
    1. Chen Z, Venkat P, Seyfried D, et al. Brain-heart interaction: cardiac complications after stroke. Circ Res. 2017;121:451–468.
    1. Chowdhury T, Mendelowith D, Golanov E, et al. Trigemino-Cardiac Reflex Examination Group. Trigeminocardiac reflex: the current clinical and physiological knowledge. J Neurosurg Anesthesiol. 2015;27:136–147.
    1. Sandu N, Chowdhury T, Meuwly C, et al. Trigeminocardiac reflex in cerebrovascular surgery: a review and an attempt of a predictive analysis. Expert Rev Cardiovasc Ther. 2017;15:203–209.
    1. Spiriev T, Kondoff S, Schaller B. Trigemino-Cardiac-Reflex-Examination-Group. Cardiovascular changes after subarachnoid hemorrhage initiated by the trigeminocardiac reflex-first description of a case series. J Neurosurg Anesthesiol. 2011;23:379–380.

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