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Clinical Trial
. 2020 Oct;60(10):2327-2339.
doi: 10.1111/trf.16005. Epub 2020 Aug 31.

Prevalence of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in United States blood donations, 2015 to 2019: The Transfusion-Transmissible Infections Monitoring System (TTIMS)

Whitney R Steele  1 , Roger Y Dodd  1 , Edward P Notari  1 , Meng Xu  1 , Diane Nelson  1 , Debra A Kessler  2 , Rita Reik  3 , Alan E Williams  4 , Brian Custer  5 , Susan L Stramer  1 ; Transfusion-Transmissible Infections Monitoring System (TTIMS)
Affiliations
Clinical Trial

Prevalence of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in United States blood donations, 2015 to 2019: The Transfusion-Transmissible Infections Monitoring System (TTIMS)

Whitney R Steele et al. Transfusion. 2020 Oct.

Abstract

Background: The Transfusion-Transmissible Infections Monitoring System (TTIMS) combines data from four US blood collection organizations including approximately 60% of all donations to monitor demographic and temporal trends in infectious disease markers and policy impacts.

Study design and methods: Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) consensus-positive definitions combined serology and nucleic acid testing results. These along with donor and donation characteristics were assembled into a single data set. Overall donation prevalence and demographic subsets were compared pre- and post-implementation of the 2015 change in men who have sex with men (MSM) deferral policy, among other prevalence comparisons.

Results: From October 2015 to September 2019, there were 712 HIV-, 1735 HBV-, and 5217 HCV-positive samples identified from approximately 27.5 million donations (>9.4 million donors). Prevalences per 100 000 donations were 2.6 (HIV), 6.3 (HBV), and 19.0 (HCV), and the highest for all three agents were in donations from first-time male donors. Two slight but significant increases in HIV prevalence were observed, both for comparisons of Year 1 (pre-MSM policy change) versus Year 4 (post-MSM policy change) for first-time males and first-time females; in contrast, similar comparisons demonstrated decreases in HCV prevalence (all donors and general trends for males and females). Except for HIV, prevalence increased with age; for all agents, prevalence was markedly higher in the south.

Conclusions: No major trends were observed over 4 years covering the MSM policy change from indefinite to a 12-month deferral, but ongoing monitoring is warranted. Demographic trends are consistent with those observed in other donor studies and community trends.

Keywords: HBV; HCV; HIV; MSM; blood safety; prevalence; transfusion-transmitted infections.

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References

REFERENCES

    1. US Food and Drug Administration. Revised Recommendations for Reducing the Risk of Human Immunodeficiency Virus Transmission by Blood and Blood Products-Guidance for Industry. Silver Spring, MD: US Food and Drug Administration, 2015.
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